Journal
JOURNAL OF CELL SCIENCE
Volume 129, Issue 22, Pages 4159-4163Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.192054
Keywords
Adhesion; Cytoskeleton; Integrin; Integrin adhesion; complex; Adhesome
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Funding
- Wellcome Trust [092015]
- Cancer Research UK [C13329/A21671]
- Biotechnology and Biological Sciences Research Council (BBSRC) studentship as part of the Systems Biology Doctoral Training Centre
- Biotechnology and Biological Sciences Research Council [1087621] Funding Source: researchfish
- Cancer Research UK [21671] Funding Source: researchfish
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The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and the accompanying poster, we integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated IAC proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localise to IACs. The resulting IAC network, which comprises four broad signalling and actin-bridging axes, provides a platform for future studies of the regulation and function of the adhesion nexus in health and disease.
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