The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis-A Pilot Study

Article Pediatrics

CFTR modulator therapies-Effect on life expectancy in people with cystic fibrosis

I. M. Balfour-Lynn et al.

Summary: CFTR modulators have significantly improved the clinical course of CF, with indirect evidence suggesting potential impact on life expectancy.

PAEDIATRIC RESPIRATORY REVIEWS (2022)

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Editorial Material Immunology

Role of the T cell vitamin D receptor in severe COVID-19

Jay K. Kolls et al.

Summary: New research has found evidence of impaired vitamin D gene signature in CD4(+) T cells in patients with severe COVID-19. It shows that vitamin D can alter the epigenetic landscape of CD4(+) T cells, induce key transcription factors, reduce levels of certain inflammatory factors, increase levels of others, and generate T(H)1 cells that are beneficial in preventing or resolving COVID-19.

NATURE IMMUNOLOGY (2022)

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Review Endocrinology & Metabolism

Possible role of vitamin D in Covid-19 infection in pediatric population

F. M. Panfili et al.

Summary: The COVID-19 pandemic requires urgent therapeutic interventions, especially for vulnerable populations such as elderly males. Vitamin D has shown promising immunomodulatory effects and may play a role in the prevention and treatment of SARS-CoV-2 infection in both adults and children.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

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Article Health Care Sciences & Services

Factors Influencing Lung Function in Patients with Cystic Fibrosis in Western Romania

Mihaela Dediu et al.

Summary: This cross-sectional study aimed to identify major factors influencing pulmonary function in CF patients, with results showing significant impact of BMI and age on lung function. The research suggests that better nutritional status and infection prophylaxis should be emphasized in the comprehensive clinical management strategy for pediatric CF patients in Romania.

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2021)

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Review Public, Environmental & Occupational Health

The role of vitamin D deficiency on COVID-19: a systematic review and meta-analysis of observational studies

Mehmet Onur Kaya et al.

Summary: The study found that low serum vitamin D levels may increase the risk of COVID-19 infection and the likelihood of severe disease. Therefore, it is recommended to supplement with vitamin D to prevent COVID-19 and its negative outcomes.

EPIDEMIOLOGY AND HEALTH (2021)

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Article Respiratory System

Longitudinal course of clinical lung clearance index in children with cystic fibrosis

Bettina S. Frauchiger et al.

Summary: This study described the longitudinal course of LCI in children with CF during routine clinical surveillance, finding a more pronounced increase in LCI during adolescence. Factors such as colonization with Pseudomonas aeruginosa or Aspergillus fumigatus, pulmonary exacerbations, CF-related diabetes, and bronchopulmonary aspergillosis were associated with a higher increase in LCI over time.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Respiratory System

Abnormal glucose tolerance and lung function in children with cystic fibrosis. Comparing oral glucose tolerance test and continuous glucose monitoring

H. Elidottir et al.

Summary: The study suggests that there is a correlation between abnormal glucose tolerance and declining lung function in children with cystic fibrosis.

JOURNAL OF CYSTIC FIBROSIS (2021)

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Article Respiratory System

Abnormal Lung Clearance Index in Cystic Fibrosis Children with Normal FEV1 and Single-Breath Nitrogen Washout Test

Ajay S. Kasi et al.

Summary: Comparing the results of respiratory tests between CF patients and healthy controls, significant differences were found in SIII and LCI in CF patients, with significant correlations between both parameters and lung function tests. In patients with normal FEV1, it is possible for LCI to be abnormal despite normal SIII.

LUNG (2021)

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Review Pediatrics

Early Diagnosis and Intervention in Cystic Fibrosis: Imagining the Unimaginable

Andrea M. Coverstone et al.

Summary: Cystic fibrosis is a common genetic disease affecting Caucasians which can shorten life expectancy. Early diagnosis and intervention have improved clinical outcomes, while newer medications are revolutionizing treatment approaches.

FRONTIERS IN PEDIATRICS (2021)

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Article Nutrition & Dietetics

Vitamin D Status in Pediatric and Young Adult Cystic Fibrosis Patients. Are the New Recommendations Effective?

Carmen Mangas-Sanchez et al.

Summary: In patients with CF, higher doses of vitamin D were associated with a decreased risk of deficiency and higher serum calcidiol levels. However, nearly one-third of CF patients still do not reach sufficient levels of vitamin D despite the new guidelines.

NUTRIENTS (2021)

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Review Public, Environmental & Occupational Health

Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

Iacopo Chiodini et al.

Summary: This meta-analysis found that vitamin D deficiency is associated with an increased risk of SARS-CoV-2 infection, COVID-19 hospitalization, ICU admission, and mortality. Patients with low vitamin D levels are more susceptible to severe outcomes of COVID-19.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Endocrinology & Metabolism

A Clinician's guide to vitamin D supplementation for patients with cystic fibrosis

Colleen Wood et al.

Summary: Vitamin D deficiency is common in patients with cystic fibrosis and can lead to poor bone health and declining pulmonary function. The Cystic Fibrosis Foundation has issued guidelines for the treatment of vitamin D deficiency, but most centers are still unable to achieve target serum vitamin D levels for their patients. Future research is needed to determine ideal treatment regimens and the impact of new triple therapy cystic fibrosis drug combinations on vitamin D-related clinical outcomes.

JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY (2021)

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Review Pediatrics

Correlation of computed tomography findings and lung function in children and adolescents with cystic fibrosis

Andrew Fretzayas et al.

Summary: Most studies have shown moderate correlations between forced expiratory volume in the first second (FEV1) and other spirometric indices with CT structural lung damage. However, there are patients with normal FEV1 but abnormal CT and vice versa at an individual level. Longitudinal studies indicate that deterioration of structural lung damage does not occur in parallel with lung function progression, and lung clearance index is a better predictor of CT findings.

WORLD JOURNAL OF PEDIATRICS (2021)

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Article Medicine, General & Internal

1,25-dihydroxyvitamin D3 regulates t helper and b lymphocyte responses substantially in drug-naive primary Sjogren's syndrome patients' mononuclear cells

Deniz Genc et al.

Summary: The results showed that 1,25-dihydroxyvitamin D3 significantly decreased Th lymphocyte proliferative responses in both drug-naive and treated pSS patients, and B lymphocyte proliferation in drug-naive pSS PBMC cultures. The study concluded that 1,25-dihydroxyvitamin D3 regulated immune responses in both treated and drug-naive pSS patients.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

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Review Nutrition & Dietetics

Vitamin D's Effect on Immune Function

Pieter-Jan Martens et al.

NUTRIENTS (2020)

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Review Pharmacology & Pharmacy

Novel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies

Christie Mitri et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19

Minkyung Bae et al.

MOLECULES (2020)

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Article Food Science & Technology

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Amir-Hossein Avestaei et al.

NUTRITION & FOOD SCIENCE (2020)

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Article Pediatrics

Vitamin D status correlates with the markers of cystic fibrosis-related pulmonary disease

Wasim Ahmad Wani et al.

PEDIATRICS AND NEONATOLOGY (2019)

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Article Gastroenterology & Hepatology

Increasing Vitamin D Serum Levels Is Associated With Reduced Pulmonary Exacerbations in Patients With Cystic Fibrosis

Yasmeen Abu-Fraiha et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2019)

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Article Pediatrics

Change in lung clearance index with microbiological status in children with cystic fibrosis

Katarzyna Walicka-Serzysko et al.

PEDIATRIC PULMONOLOGY (2019)

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Article Respiratory System

Vitamin D deficiency and its treatment in cystic fibrosis

Tanicia Daley et al.

JOURNAL OF CYSTIC FIBROSIS (2019)

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Letter Respiratory System

Airway infection, systemic inflammation and lung clearance index in children and adults with cystic fibrosis

Katherine O'Neill et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Respiratory System

Children with cystic fibrosis demonstrate no respiratory immunological, infective or physiological, consequences of vitamin D deficiency

Rebecca M. Thursfield et al.

JOURNAL OF CYSTIC FIBROSIS (2018)

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Article Respiratory System

P205 Influences on vitamin D in cystic fibrosis patients

M. Dediu et al.

Journal of Cystic Fibrosis (2018)

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Review Medicine, Research & Experimental

Vitamin D in Cardiovascular Disease

Alkippi Nitsa et al.

IN VIVO (2018)

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Review Respiratory System

The new reference equations of the Global Lung function Initiative (GLI) for pulmonary function tests

A. Guillien et al.

REVUE DES MALADIES RESPIRATOIRES (2018)

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Review Nutrition & Dietetics

Vitamin D: Nutrient, Hormone, and Immunomodulator

Francesca Sassi et al.

NUTRIENTS (2018)

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Review Endocrinology & Metabolism

Updates in vitamin D therapy in cystic fibrosis

Trang N. Le

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2018)

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Article Nutrition & Dietetics

Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial

T. Pincikova et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2017)

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Review Virology

Vitamin D modulation of innate immune responses to respiratory viral infections

Mihnea T. Zdrenghea et al.

REVIEWS IN MEDICAL VIROLOGY (2017)

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Article Pediatrics

Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation

Philip M. Farrell et al.

JOURNAL OF PEDIATRICS (2017)

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Review Critical Care Medicine

Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis What Have We Learned and What Should We Do about It?

Sarath C. Ranganathan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Article Respiratory System

Age and height dependence of lung clearance index and functional residual capacity

Sooky Lum et al.

EUROPEAN RESPIRATORY JOURNAL (2013)

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Article Endocrinology & Metabolism

An Update on the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals with Cystic Fibrosis: Evidence-Based Recommendations from the Cystic Fibrosis Foundation

V. Tangpricha et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Article Biochemistry & Molecular Biology

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3

AF Gombart et al.

FASEB JOURNAL (2005)

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Cutting edge:: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression

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The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells

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The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis-A Pilot Study

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