Journal
JOURNAL OF CELL SCIENCE
Volume 129, Issue 14, Pages 2778-2792Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.182824
Keywords
Early endosomes; mRNA transport; Septin; RNA recognition motif
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Funding
- Deutsche Forschungsgemeinschaft [EXC 1028, DFG FE448/9-1, CRC1208]
- iGRAD Molecules of Infection (MOI) programme
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Septins are conserved cytoskeletal structures functioning in a variety of biological processes including cytokinesis and cell polarity. A wealth of information exists on the heterooligomeric architecture of septins and their subcellular localization at distinct sites. However, the precise mechanisms of their subcellular assembly and their intracellular transport are unknown. Here, we demonstrate that endosomal transport of septins along microtubules is crucial for formation of higher-order structures in the fungus Ustilago maydis. Importantly, endosomal septin transport is dependent on each individual septin providing strong evidence that septin heteromeric complexes are assembled on endosomes. Furthermore, endosomal trafficking of all four septin mRNAs is required for endosomal localization of their translation products. Based on these results, we propose that local translation promotes the assembly of newly synthesized septins in heteromeric structures on the surface of endosomes. This is important for the long-distance transport of septins and the efficient formation of the septin cytoskeleton.
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