Journal
JOURNAL OF CELL SCIENCE
Volume 130, Issue 1, Pages 63-70Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.198630
Keywords
3D model; Microtissue; Contractility; Extracellular matrix; TFM
Categories
Funding
- National Institutes of Health [HL080494]
- National Institute of Biomedical Imaging and Bioengineering [EB017103]
- National Science Foundation [CMMI-1462710]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1462710] Funding Source: National Science Foundation
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Cells dynamically assemble and organize into complex tissues during development, and the resulting three-dimensional (3D) arrangement of cells and their surrounding extracellular matrix in turn feeds back to regulate cell and tissue function. Recent advances in engineered cultures of cells to model 3D tissues or organoids have begun to capture this dynamic reciprocity between form and function. Here, we describe the underlying principles that have advanced the field, focusing in particular on recent progress in using mechanical constraints to recapitulate the structure and function of musculoskeletal tissues.
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