Journal
JOURNAL OF CELL SCIENCE
Volume 129, Issue 24, Pages 4439-4447Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.194753
Keywords
Annulate lamellae; Nuclear envelope; Nuclear pore complex; Nuclear transport
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Funding
- European Research Council [309528 CHROMDECON]
- Heisenberg fellowship of the Deutsche Forschungsgemeinschaft [DFG AN 377/6-1]
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The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) that are embedded within the nuclear envelope, and control molecular exchange between the cytoplasm and nucleoplasm. In this Commentary, we discuss the biogenesis of these huge protein assemblies from approximately one thousand individual proteins. We will summarize current knowledge about distinct assembly modes in animal cells that are characteristic for different cell cycle phases and their regulation.
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