Journal
IMMUNITY INFLAMMATION AND DISEASE
Volume 10, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/iid3.595
Keywords
B-cell; IFN gamma; IL-2; SARS-Cov-2; T cell
Categories
Funding
- Leif Lundblad Family Foundation
- Science for Life Laboratory
- Erling Persson Family Foundation
- Jonas & Kristina af Jochnick Foundation
- Hjart-Lungfonden [20190468]
- Vetenskapsradet [2018-02552, 2020-05782]
- Svenska Sallskapet for Medicinsk Forskning
- Region Stockholm
- Knut och Alice Wallenbergs Stiftelse [2020-05880]
- Swedish Heart-Lung Foundation [20190468] Funding Source: Swedish Heart-Lung Foundation
- Swedish Research Council [2020-05782, 2018-02552] Funding Source: Swedish Research Council
Ask authors/readers for more resources
This study investigates the correlation between symptomology and cellular immune responses post seroconversion to COVID-19. The findings demonstrate that the severity of the disease and specific COVID-19 symptoms are correlated with the magnitude of SARS-CoV-2-specific memory T cell responses. The study highlights the importance of cellular immune memory in understanding the immune response to COVID-19.
Background: Cellular immune memory responses post coronavirus disease 2019 (COVID-19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The work herein presents a large-scale long-term follow-up study investigating the correlation between symptomology and cellular immune responses four to five months post seroconversion based on a unique severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific peptide pool that contains no overlapping peptides with endemic human coronaviruses. Methods: Peptide stimulated memory T cell responses were assessed with dual interferon-gamma (IFN gamma) and interleukin (IL)-2 Fluorospot. Serological analyses were performed using a multiplex antigen bead array. Results: Our work demonstrates that long-term SARS-CoV-2-specific memory T cell responses feature dual IFN gamma and IL-2 responses, whereas cross-reactive memory T cell responses primarily generate IFN gamma in response to SARS-CoV-2 peptide stimulation. T cell responses correlated to long-term humoral immune responses. Disease severity as well as specific COVID-19 symptoms correlated with the magnitude of the SARS-CoV-2-specific memory T cell response four to five months post seroconversion. Conclusion: Using a large cohort and a SARS-CoV-2-specific peptide pool we were able to substantiate that initial disease severity and symptoms correlate with the magnitude of the SARS-CoV-2-specific memory T cell responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available