Journal
LIFE SCIENCE ALLIANCE
Volume 5, Issue 6, Pages -Publisher
LIFE SCIENCE ALLIANCE LLC
DOI: 10.26508/lsa.202101229
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Funding
- The Swarnajayanti Fellowship [DST/SJF/LSA-03/2014-15]
- CSIR [MLP-139, MLP-136]
- Indo-Swiss Bilateral Project Grant from Department of Biotechnology, Govt of India [BT/IN/Swiss/53/SNB/2018-19]
- CSIR
- National Bioscience Award Fund from Department of Biotechnology, Government of India
- University Grant Commission, India
- CSIR, India
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Leishmania regulates host cell miRNA transport to restrict inflammation. It inhibits inflammation by preventing host cell uptake of miR-122-containing vesicles and promotes inflammation by up-regulating the export of miR-146a, which affects cytokine expression and polarization of other macrophages.
Leishmania donovani, the causative agent of visceral leishmaniasis, infects and resides within tissue macrophage cells. It is not clear how the parasite infected cells crosstalk with the noninfected cells to regulate the infection process. During infection, Leishmania adopts a dual strategy for its survival by regulating the intercellular transport of host miRNAs to restrict inflammation. The parasite, by preventing mitochondrial function of host cells, restricts the entry of liver cell derived miR-122-containing extracellular vesicles in infected macrophages to curtail the inflammatory response associated with miR-122 entry. On contrary, the parasite up-regulates the export of miR-146a from the infected macrophages. The miR-146a, associated with the extracellular vesicles released by infected cells, restricts miR-122 production in hepatocytes while polarizing neighbouring naive macrophages to the M2 state by affecting the cytokine expression. On entering the recipient macrophages, miR-146a dominates the miRNA antagonist RNA-binding protein HuR to inhibit the expression of proinflammatory cytokine mRNA5 having HuR-interacting AU-rich elements whereas up-regulates anti-inflammatory IL-10 by exporting the miR-21 to polarize the recipient cells to M2 stage.
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