4.6 Review

Developing Community Resources for Nucleic Acid Structures

Journal

LIFE-BASEL
Volume 12, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/life12040540

Keywords

nucleic acid structures; nucleic acid conformation; biological structure database; DNA; RNA; validation standards

Funding

  1. National Science Foundation
  2. Ministry of Education, Youth, and Sports of the Czech Republic [LTAUSA18197]
  3. Institute of Biotechnology of the Czech Academy of Sciences [RVO 86652036]
  4. National Institutes of Health General Medical Sciences [R01 GM079429, R01 GM085238]

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This review discusses the establishment and utilization of the Nucleic Acid Database (NDB) as a testing ground for the RCSB Protein Data Bank infrastructure. It highlights the unique features of the NDB and its contribution to research efforts. Furthermore, the future plans for the Nucleic Acid Knowledgebase (NAKB) are outlined.
In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers University and how it became a testbed for the current infrastructure of the RCSB Protein Data Bank. We describe some of the special features of the NDB and how it has been used to enable research. Plans for the next phase as the Nucleic Acid Knowledgebase (NAKB) are summarized.

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