Journal
BIOSENSORS-BASEL
Volume 12, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/bios12040241
Keywords
screen-printed sensor; boron-doped diamond electrode; preparation; characterization; electrochemical properties; analytical application; lornoxicam
Funding
- Czech Science Foundation [20-01589S]
- University of Pardubice [SGSFChT_2022_001]
- VEGA [1/0554/20]
- European Regional Development Fund
- Operational Program Integrated Infrastructure [313011ASS8]
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A new screen-printed sensor with a boron-doped diamond working electrode was fabricated using a large-area linear antenna microwave chemical deposition vapor system. The sensor combines the advantages of disposable printed sensors with the excellent electrochemical properties of the boron-doped diamond electrode. The sensor's feasibility and applicability were verified through various experiments and analysis.
New screen-printed sensor with a boron-doped diamond working electrode (SP/BDDE) was fabricated using a large-area linear antenna microwave chemical deposition vapor system (LA-MWCVD) with a novel precursor composition. It combines the advantages of disposable printed sensors, such as tailored design, low cost, and easy mass production, with excellent electrochemical properties of BDDE, including a wide available potential window, low background currents, chemical resistance, and resistance to passivation. The newly prepared SP/BDDEs were characterized by scanning electron microscopy (SEM) and Raman spectroscopy. Their electrochemical properties were investigated by cyclic voltammetry and electrochemical impedance spectroscopy using inner sphere ([Fe(CN)(6)](4-/3-)) and outer sphere ([Ru(NH3)(6)](2+/3+)) redox probes. Moreover, the applicability of these new sensors was verified by analysis of the anti-inflammatory drug lornoxicam in model and pharmaceutical samples. Using optimized differential pulse voltammetry in Britton-Robinson buffer of pH 3, detection limits for lornoxicam were 9 x 10(-8) mol L-1. The oxidation mechanism of lornoxicam was investigated using bulk electrolysis and online electrochemical cell with mass spectrometry; nine distinct reaction steps and corresponding products and intermediates were identified.
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