Journal
BIOSENSORS-BASEL
Volume 12, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/bios12040195
Keywords
biosensor; portable; fluorescence; waveguide; evanescent field
Funding
- Laboratory Directed Research and Development program of Los Alamos National Laboratory [20180387ER]
- Defense Threat Reduction Agency [HDTRA R-00634-19-0]
- Congressionally Directed Medical Research Program of the U.S. Department of Defense [R-00674-19-0]
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Rapid on-site diagnostics are crucial for timely intervention and response in warfare, environmental monitoring, and global health. Portable optical biosensors are being extensively researched as a means of achieving fast and accurate fieldable biosensing. The portable engineered analytic sensor with automated sampling (PEGASUS) has been developed as a fieldable, generalizable biosensing platform.
Rapid, on-site diagnostics allow for timely intervention and response for warfighter support, environmental monitoring, and global health needs. Portable optical biosensors are being widely pursued as a means of achieving fieldable biosensing due to the potential speed and accuracy of optical detection. We recently developed the portable engineered analytic sensor with automated sampling (PEGASUS) with the goal of developing a fieldable, generalizable biosensing platform. Here, we detail the development of PEGASUS's sensing hardware and use a test-bed system of identical sensing hardware and software to demonstrate detection of a fluorescent conjugate at 1 nM through biotin-streptavidin chemistry.
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