Journal
JOURNAL OF CELL BIOLOGY
Volume 213, Issue 1, Pages 23-32Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201512029
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Funding
- National Science Foundation [MCB-507511]
- National Institutes of Health [NIGMS-T32GM008704]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1212400] Funding Source: National Science Foundation
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Cells change shape in response to diverse environmental and developmental conditions, creating topologies with micron-scale features. Although individual proteins can sense nanometer-scale membrane curvature, it is unclear if a cell could also use nanometer-scale components to sense micron-scale contours, such as the cytokinetic furrow and base of neuronal branches. Septins are filament-forming proteins that serve as signaling platforms and are frequently associated with areas of the plasma membrane where there is micron-scale curvature, including the cytokinetic furrow and the base of cell protrusions. We report here that fungal and human septins are able to distinguish between different degrees of micron-scale curvature in cells. By preparing supported lipid bilayers on beads of different curvature, we reconstitute and measure the intrinsic septin curvature preference. We conclude that micron-scale curvature recognition is a fundamental property of the septin cytoskeleton that provides the cell with a mechanism to know its local shape.
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