Journal
JOURNAL OF CELL BIOLOGY
Volume 212, Issue 1, Pages 13-27Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201510032
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research
Ask authors/readers for more resources
Examples of associations between human disease and defects in pre-messenger RNA splicing/alternative splicing are accumulating. Although many alterations are caused by mutations in splicing signals or regulatory sequence elements, recent studies have noted the disruptive impact of mutated generic spliceosome components and splicing regulatory proteins. This review highlights recent progress in our understanding of how the altered splicing function of RNA-binding proteins contributes to myelodys-plastic syndromes, cancer, and neuropathologies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available