Journal
JOURNAL OF CELL BIOLOGY
Volume 213, Issue 6, Pages 617-629Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201602089
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Funding
- National Institutes of Health [AR056296, CA163507, AI101935, AI124346]
- American Lebanese Syrian Associated Charities
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Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1 beta and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.
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