The Role of Rituximab in Primary Focal Segmental Glomerular Sclerosis of the Adult

Article Urology & Nephrology

Mycophenolate Mofetil after Rituximab for Childhood-Onset Complicated Frequently-Relapsing or Steroid-Dependent Nephrotic Syndrome

Kazumoto Iijima et al.

Summary: Administration of MMF after rituximab may be effective in preventing treatment failure and is well tolerated.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Urology & Nephrology

Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology

Andrew J. B. Watts et al.

Summary: In a subset of patients with minimal change disease, circulating nephrin autoantibodies were detected during active disease but significantly reduced or absent during treatment response. These autoantibodies were correlated with podocyte-associated punctate IgG in renal biopsies. A steroid-dependent patient with childhood minimal change disease developed end stage kidney disease, with high pretransplant circulating nephrin autoantibodies associated with massive post-transplant recurrence of proteinuria.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Transplantation

Safety and efficacy of dapagliflozin in patients with focal segmental glomerulosclerosis: a prespecified analysis of the dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial

David C. Wheeler et al.

Summary: In a study involving FSGS patients, dapagliflozin was found to reduce the rate of chronic eGFR decline compared to placebo, although this difference was not statistically significant.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Article Transplantation

Proteinuria selectivity index predicts response to rituximab in adults with minimal change disease and focal segmental glomerulosclerosis

Marco Allinovi et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Article Urology & Nephrology

Efficacy of Rituximab in Treatment-Resistant Focal Segmental Glomerulosclerosis With Elevated Soluble Urokinase-Type Plasminogen Activator Receptor and Activation of Podocyte β3 Integrin

Michelle A. Hladunewich et al.

Summary: In this study, the use of rituximab in adult patients with treatment-resistant primary FSGS, high suPAR levels, and evidence of podocyte activation was found to be ineffective in improving proteinuria levels and glomerular filtration rate.

KIDNEY INTERNATIONAL REPORTS (2022)

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Review Immunology

Therapies for Membranous Nephropathy: A Tale From the Old and New Millennia

Francesco Scolari et al.

Summary: Primary Membranous Nephropathy (PMN) is the most common cause of nephrotic syndrome in adults and can lead to end-stage renal disease if left untreated. This review discusses the evidence for different immunosuppressive regimens used for PMN and provides recommendations based on current evidence. The association of PMN with HLA-DQA1 and the presence of autoantibodies support the autoimmune nature of the disease.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Urology & Nephrology

KDIGO 2021 CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF GLOMERULAR DISEASES

Brad H. Rovin et al.

Summary: The KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases aims to assist clinicians caring for individuals with glomerular disease by providing actionable recommendations and valuable infographics. It also proposes research recommendations for areas where there are gaps in knowledge, targeting a broad audience of clinicians treating glomerular disease. The guideline development process followed an explicit evidence review and the treatment approaches are based on systematic reviews, evidence synthesis, and the GRADE approach.

KIDNEY INTERNATIONAL (2021)

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Article Urology & Nephrology

Primary Nephrotic Syndrome and Risks of ESKD, Cardiovascular Events, and Death: The Kaiser Permanente Nephrotic Syndrome Study

Alan S. Go et al.

Summary: This study showed that adults with primary nephrotic syndrome have higher risks of ESKD, cardiovascular events, and death. There were significant differences in the risk of developing ESKD based on underlying etiologies.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology