Humoral Response to Heterologous SARS-CoV-2 Vaccination in Kidney Transplant Patients Is Heterogeneous and Dose Dependent

Letter Medicine, General & Internal

Antibody Response to a Fourth Messenger RNA COVID-19 Vaccine Dose in Kidney Transplant Recipients: A Case Series

Sophie Caillard et al.

ANNALS OF INTERNAL MEDICINE (2022)

Article Transplantation

Safety and immediate humoral response of COVID-19 vaccines in chronic kidney disease patients: the SENCOVAC study

Borja Quiroga et al.

Summary: This study aims to describe the humoral response and safety of COVID-19 vaccines in CKD patients. The results show that most CKD patients develop antibodies after vaccination, but kidney transplant patients have a lower antibody response rate, suggesting the need for additional isolation measures and booster doses of the vaccine.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Article Multidisciplinary Sciences

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

Catherine J. Reynolds et al.

Summary: The study found that the initial strain of SARS-CoV-2 infection's impact on downstream immunity to heterologous variants of concern (VOCs) is unknown. After three antigen exposures, neutralization potency against different VOCs changed, and serology poorly predicted neutralizing immunity. Heterologous combinations of spike encountered during infection and vaccination shape subsequent cross-protection against VOCs.

SCIENCE (2022)

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Article Urology & Nephrology

Comparison of antibody response to SARS-CoV-2 after two doses of inactivated virus and BNT162b2 mRNA vaccines in kidney transplant

Mariana Seija et al.

Summary: The antibody response against SARS-CoV-2 after vaccination is weak in kidney transplant patients, especially those who received inactivated virus-based vaccines. Strategies are needed to improve the immunogenicity in this population.

CLINICAL KIDNEY JOURNAL (2022)

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Letter Medicine, General & Internal

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses

Ilies Benotmane et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Urology & Nephrology

A third vaccine dose substantially improves humoral and cellular SARS-CoV-2 immunity in renal transplant recipients with primary humoral nonresponse

Timm H. Westhoff et al.

KIDNEY INTERNATIONAL (2021)

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Editorial Material Urology & Nephrology

Immune response to SARSCoV-2 infection and vaccination in patients receiving kidney replacement therapy

T. Alp Ikizler et al.

Summary: This issue of Kidney International summarizes the initial experience regarding the immunogenicity of prior COVID-19 infection and the response to COVID-19 vaccines among patients on maintenance dialysis and kidney transplant recipients. Preliminary data suggest durability of immune response after COVID-19 infection, with a significant portion of dialysis patients developing robust antibody titers after the second vaccine dose, while kidney transplant recipients show a less-strong immune response.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine

Ilies Benotmane et al.

KIDNEY INTERNATIONAL (2021)

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Humoral Response to Heterologous SARS-CoV-2 Vaccination in Kidney Transplant Patients Is Heterogeneous and Dose Dependent

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