Journal
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
Volume 11, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s40164-022-00281-2
Keywords
N6-methyladenosine; Tumor immunity; Immune escape; Immunotherapy
Categories
Funding
- National Natural Science Foundation of China [81502530, 82172976, 82103597]
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N6-methyladenosine modification plays an important role in tumor by regulating tumor immune escape, immune cell responses in the tumor microenvironment, and is closely associated with immunotherapy.
As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor. m6A can participate in the regulation of tumor immune escape, so as to enhance the monitoring of tumor by the immune system and reduce tumorgenesis. m6A can also affect the tumor progression by regulating the immune cell responses to tumor in tumor microenvironment. In addition, immunotherapy has become the most popular method for the treatment of cancer, in which targets such as immune checkpoints are also closely associated with m6A. This review discusses the roles of N6-methyladenosine modification in tumor immune regulation, their regulatory mechanism, and the prospect of immunotherapy.
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