Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review

Liver transplantation (LT) is one of the most effective treatments for hepatocellular carcinoma (HCC). Although LT eliminates HCC and greatly reduces recurrence, some patients experience recurrence after LT. Criteria and models for screening patients with a high probability of HCC recurrence after LT, starting with the Milan criteria, have been published. These models have changed over time, but a standard has not been established. We summarized HCC prediction models after LT by focusing on the application of radiologic, serologic, and pathologic factors and recent trends. This review will look at studies that are based on living donor LT and deceased donor LT, as well as studies that downstaging procedures have been performed preoperatively. This ultimately aims to help make decisions for evaluating the HCC state and selecting candidates for LT according to the circumstances of each transplantation center.

Automated summary

Liver transplantation is an effective treatment for hepatocellular carcinoma, but some patients still experience recurrence after transplantation. Prediction models for HCC recurrence after transplantation have been published, but a standard has not been established. This review summarizes the latest prediction models for HCC recurrence after liver transplantation, focusing on radiologic, serologic, and pathologic factors, and includes studies on living donor and deceased donor transplantation.