Delivering therapeutic proteins in vivo by engineered DNA-free virus-like particles

Many genetic disorders are a result of single or multiple genome abnormalities. A possible approach to circumvent genetic disorders is to use gene editing agents to correct these mistakes, but a major challenge remains in the mode of delivery of gene editing agents to different regions of the body. Banskota et al. present the use of engineered DNA-free virus-like particles (eVLPs) to deliver base editors to different organs in a mice model for improved outcomes, highlighting the potential of eVLPS to deliver base editors and as an efficient delivery mechanism, leveraging the advantages of viral and nonviral delivery methods.

Automated summary

Gene editing agents can be delivered using engineered DNA-free virus-like particles (eVLPs) to different organs, leading to improved outcomes in overcoming genetic disorders.