Related references
Note: Only part of the references are listed.Impaired bone marrow microenvironment and stem cells in transfusion-dependent beta-thalassemia
Xiaoya Zhou et al.
BIOMEDICINE & PHARMACOTHERAPY (2022)
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow
Dachuan Zhang et al.
CELL STEM CELL (2022)
Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: the HGB-205 trial
Elisa Magrin et al.
NATURE MEDICINE (2022)
Betibeglogene Autotemcel Gene Therapy for Non-β0/β0 Genotype β-Thalassemia
Franco Locatelli et al.
NEW ENGLAND JOURNAL OF MEDICINE (2022)
Acute Myeloid Leukemia Case after Gene Therapy for Sickle Cell Disease
Sunita Goyal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2022)
Inhibition of Fibroblast Growth Factor-23 (FGF-23) Rescues Bone and Hematopoietic Stem Cell Niche Defects in BetaThalassemia, Uncovering the Missing Link between Hematopoiesis and Bone
Annamaria Aprile et al.
BLOOD (2021)
Gene therapy using haematopoietic stem and progenitor cells
Giuliana Ferrari et al.
NATURE REVIEWS GENETICS (2021)
Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
Erica B. Esrick et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
H. Frangoul et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
β-Thalassemias
Ali T. Taher et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
Murine bone marrow mesenchymal stromal cells have reduced hematopoietic maintenance ability in sickle cell disease
Alice Tang et al.
BLOOD (2021)
FGF23 at the crossroads of phosphate, iron economy and erythropoiesis
Daniel Edmonston et al.
NATURE REVIEWS NEPHROLOGY (2020)
Oral ferroportin inhibitor VIT-2763: First-in-human, phase 1 study in healthy volunteers
Frank Richard et al.
AMERICAN JOURNAL OF HEMATOLOGY (2020)
Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion
Shin-Young Park et al.
BLOOD (2020)
Live-animal imaging of native haematopoietic stem and progenitor cells
Constantina Christodoulou et al.
NATURE (2020)
Dynamic responses of the haematopoietic stem cell niche to diverse stresses
Antoniana Batsivari et al.
NATURE CELL BIOLOGY (2020)
Hematopoietic stem cell function in beta-thalassemia is impaired and is rescued by targeting the bone marrow niche
Annamaria Aprile et al.
BLOOD (2020)
A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia
M. D. Cappellini et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Targeting the bone marrow niche in hemoglobinopathies
Nadia Carlesso
BLOOD (2020)
Regulation of the Bone Marrow Niche by Inflammation
Ioannis Mitroulis et al.
FRONTIERS IN IMMUNOLOGY (2020)
Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
Allison N. Seyfried et al.
FRONTIERS IN IMMUNOLOGY (2020)
Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells
Seda S. Tolu et al.
CELLS (2020)
Bone marrow niches in haematological malignancies
Simon Mendez-Ferrer et al.
NATURE REVIEWS CANCER (2020)
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity
Stefania Crippa et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Haematopoietic stem cell activity and interactions with the niche
Sandra Pinho et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Ninib Baryawno et al.
CELL (2019)
Haematopoietic stem cells in perisinusoidal niches are protected from ageing
Mehmet Sacma et al.
NATURE CELL BIOLOGY (2019)
Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia
Peng Hua et al.
BLOOD (2019)
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent β-thalassemia
Sarah Marktel et al.
NATURE MEDICINE (2019)
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells
Meng Zhao et al.
CELL REPORTS (2019)
Related and unrelated donor transplantation for β-thalassemia major: results of an international survey
Chunfu Li et al.
BLOOD ADVANCES (2019)
Granulocyte-derived TNF alpha promotes vascular and hematopoietic regeneration in the bone marrow
Emily Bowers et al.
NATURE MEDICINE (2018)
Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function
Darren Q. Tan et al.
ANTIOXIDANTS & REDOX SIGNALING (2018)
Gene therapy and gene editing strategies for hemoglobinopathies
Maria Rosa Lidonnici et al.
BLOOD CELLS MOLECULES AND DISEASES (2018)
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine
Yuichi Hirata et al.
CELL STEM CELL (2018)
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML
Delfim Duarte et al.
CELL STEM CELL (2018)
Complication free survival long-term after hemopoietic cell transplantation in thalassemia
Emanuele Angelucci
HAEMATOLOGICA (2018)
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Maria Maryanovich et al.
NATURE MEDICINE (2018)
Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia
A. A. Thompson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance
Matthew Decker et al.
SCIENCE (2018)
Complication free survival long-term after hemopoietic cell transplantation in thalassemia
Emanuele Angelucci
HAEMATOLOGICA (2018)
Sickle cell disease
Gregory J. Kato et al.
NATURE REVIEWS DISEASE PRIMERS (2018)
How I manage medical complications of β-thalassemia in adults
Ali T. Taher et al.
BLOOD (2018)
M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion
Yi Luo et al.
BLOOD ADVANCES (2018)
Long-term outcome of mixed chimerism after stem cell transplantation for thalassemia major conditioned with busulfan and cyclophosphamide
N. A. Fouzia et al.
BONE MARROW TRANSPLANTATION (2018)
Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation
Eliane Gluckman et al.
BLOOD (2017)
G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2
Yuko Kawano et al.
BLOOD (2017)
Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow
Erica L. Clinkenbeard et al.
HAEMATOLOGICA (2017)
Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF
Bo O. Zhou et al.
NATURE CELL BIOLOGY (2017)
Gene Therapy in a Patient with Sickle Cell Disease
Jean-Antoine Ribeil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Gene Therapy with Hematopoietic Stem Cells: The Diseased Bone Marrow's Point of View
Marina Cavazzana et al.
STEM CELLS AND DEVELOPMENT (2017)
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
Yoshiharu Muto et al.
NATURE COMMUNICATIONS (2017)
Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow
Erica L. Clinkenbeard et al.
HAEMATOLOGICA (2017)
Long-term survival of beta thalassemia major patients treated with hematopoietic stem cell transplantation compared with survival with conventional treatment
Giovanni Caocci et al.
AMERICAN JOURNAL OF HEMATOLOGY (2017)
Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients
Panjaree Siwaponanan et al.
BLOOD (2017)
Bone Marrow-Derived Mesenchymal Stromal Cells from Patients with Sickle Cell Disease Display Intact Functionality
Elizabeth O. Stenger et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2017)
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease
Francesca Vinchi et al.
BLOOD (2016)
Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
Dachuan Zhang et al.
BLOOD (2016)
Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera
Carla Casu et al.
BLOOD (2016)
Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000-2010
D. Baronciani et al.
BONE MARROW TRANSPLANTATION (2016)
CD82/KAI1 Maintains the Dormancy of Long- Term Hematopoietic Stem Cells through Interaction with DARC- Expressing Macrophages
Jin Hur et al.
CELL STEM CELL (2016)
Bone Disease in Thalassemia: A Molecular and Clinical Overview
Phillip Wong et al.
ENDOCRINE REVIEWS (2016)
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency
Asuka Terashima et al.
IMMUNITY (2016)
Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions
Maren Weisser et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)
Distinct bone marrow blood vessels differentially regulate haematopoiesis
Tomer Itkin et al.
NATURE (2016)
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
Eric M. Pietras et al.
NATURE CELL BIOLOGY (2016)
Animal models of β-hemoglobinopathies: utility and limitations
Bradley McColl et al.
JOURNAL OF BLOOD MEDICINE (2016)
Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease
Luca Dalle Carbonare et al.
BLOOD (2015)
CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance
Lauren A. Pitt et al.
CANCER CELL (2015)
Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow
Min Hee Park et al.
EMBO JOURNAL (2015)
Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3
Pauline Rimmele et al.
EMBO REPORTS (2015)
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow
Ayako Nakamura-Ishizu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Microarchitectural and mechanical characterization of the sickle bone
Mykel Green et al.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2015)
Neutrophil ageing is regulated by the microbiome
Dachuan Zhang et al.
NATURE (2015)
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Dagmar Walter et al.
NATURE (2015)
Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1
Bo O. Zhou et al.
ELIFE (2015)
ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice
Xiao Chai et al.
SCIENTIFIC REPORTS (2015)
Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis
Steffen Boettcher et al.
BLOOD (2014)
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
Grace Chen et al.
BLOOD (2014)
Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells
Christian M. Schuerch et al.
CELL STEM CELL (2014)
Stem cells and the impact of ROS signaling
Carolina L. Bigarella et al.
DEVELOPMENT (2014)
The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice
Hiroshi Okabe et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2014)
Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel
Emanuele Angelucci et al.
HAEMATOLOGICA (2014)
The bone marrow niche for haematopoietic stem cells
Sean J. Morrison et al.
NATURE (2014)
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells
Meng Zhao et al.
NATURE MEDICINE (2014)
Hematopoietic stem cell niche maintenance during homeostasis and regeneration
Avital Mendelson et al.
NATURE MEDICINE (2014)
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion
Ingmar Bruns et al.
NATURE MEDICINE (2014)
The α-Thalassemias
Frederic B. Piel et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
Deborah Chiabrando et al.
FRONTIERS IN PHARMACOLOGY (2014)
Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies
Deepa Manwani et al.
BLOOD (2013)
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Maria Casanova-Acebes et al.
CELL (2013)
Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies
Chacko Joseph et al.
CELL STEM CELL (2013)
CXCL12 in early mesenchymal progenitors is. required for haematopoietic stem-cell maintenance
Adam Greenbaum et al.
NATURE (2013)
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
Lei Ding et al.
NATURE (2013)
The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Paolo Bianco et al.
NATURE MEDICINE (2013)
Tie2+ Bone Marrow Endothelial Cells Regulate Hematopoietic Stem Cell Regeneration Following Radiation Injury
Phuong L. Doan et al.
STEM CELLS (2013)
The ageing haematopoietic stem cell compartment
Hartmut Geiger et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Phase II Trial of Parathyroid Hormone after Double Umbilical Cord Blood Transplantation
Karen Ballen et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2012)
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia
Antonella Nai et al.
BLOOD (2012)
Endothelial and perivascular cells maintain haematopoietic stem cells
Lei Ding et al.
NATURE (2012)
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow
Aya Ludin et al.
NATURE IMMUNOLOGY (2012)
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
Ingrid G. Winkler et al.
NATURE MEDICINE (2012)
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
Eri Taniguchi Ishikawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease
Elisabeth H. Javazon et al.
ANEMIA (2012)
Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency
Robert Sokolic et al.
BLOOD (2011)
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Satoshi Yamazaki et al.
CELL (2011)
Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain?
Patrick T. McGann et al.
CURRENT OPINION IN HEMATOLOGY (2011)
Predictors of osteoclast activity in patients with sickle cell disease
Mehdi Nouraie et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche
Joji Fujisaki et al.
NATURE (2011)
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response
Katherine Y. King et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Bone loss caused by iron overload in a murine model: importance of oxidative stress
Jaime Tsay et al.
BLOOD (2010)
Changes in Bone Microarchitecture and Biomechanical Properties in the th3 Thalassemia Mouse are Associated with Decreased Bone Turnover and Occur During the Period of Bone Accrual
Maria G. Vogiatzi et al.
CALCIFIED TISSUE INTERNATIONAL (2010)
The Population Genetics and Dynamics of the Thalassemias
D. J. Weatherall et al.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2010)
Involvement of Integrins α3β1 and α5β1 and Glycoprotein IIb in Megakaryocyte-Induced Osteoblast Proliferation
Justin M. Lemieux et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2010)
Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
Megan T. Baldridge et al.
NATURE (2010)
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simon Mendez-Ferrer et al.
NATURE (2010)
Beta-thalassemia
Renzo Galanello et al.
ORPHANET JOURNAL OF RARE DISEASES (2010)
N-Cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells
Wein Frederik et al.
STEM CELL RESEARCH (2010)
Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation
Massimo Dominici et al.
BLOOD (2009)
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency
Aisha V. Sauer et al.
BLOOD (2009)
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
Satoru Morikawa et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Olaia Naveiras et al.
NATURE (2009)
IFNα activates dormant haematopoietic stem cells in vivo
Marieke A. G. Essers et al.
NATURE (2009)
Global epidemiology of haemoglobin disorders and derived service indicators
Bernadette Modell et al.
BULLETIN OF THE WORLD HEALTH ORGANIZATION (2008)
Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation
Andreia A. Canalli et al.
HAEMATOLOGICA (2008)
Haematopoietic stem cell release is regulated by circadian oscillations
Simon Mendez-Ferrer et al.
NATURE (2008)
Non-traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia
C. Seguin et al.
RHEUMATOLOGY (2008)
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
Hiroki Yoshihara et al.
CELL STEM CELL (2007)
Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
Benedetto Sacchetti et al.
CELL (2007)
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Yoon-Young Jang et al.
BLOOD (2007)
Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin
Jose Villagra et al.
BLOOD (2007)
Therapeutic targeting of a stem cell niche
Gregor B. Adams et al.
NATURE BIOTECHNOLOGY (2007)
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
Tatsuki Sugiyama et al.
IMMUNITY (2006)
Medical progress:: β-thalassemia
D Rund et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
SK Nilsson et al.
BLOOD (2005)
Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis
C Baldwin et al.
BLOOD (2005)
Megakaryocytes modulate osteoblast synthesis of type-1 collagen, osteoprotegerin, and RANKL
S Bord et al.
BONE (2005)
Bone involvement in sickle cell disease
A Almeida et al.
BRITISH JOURNAL OF HAEMATOLOGY (2005)
Inflammatory potential of neutrophils detected in sickle cell disease
AFH Lum et al.
AMERICAN JOURNAL OF HEMATOLOGY (2004)
New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia
E Voskaridou et al.
BRITISH JOURNAL OF HAEMATOLOGY (2004)
Osteoblastic cells regulate the haematopoietic stem cell niche
LM Calvi et al.
NATURE (2003)
A defect in hematopoietic stem cell migration explains the nonrandorn X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome
C Lacout et al.
BLOOD (2003)
Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
K Kobayashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)