4.6 Article

Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

Related references

Note: Only part of the references are listed.
Article Immunology

Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages

Shujun Ran et al.

Summary: This study aimed to investigate the pathogenicity of Enterococcus faecalis and the molecular mechanisms of IL-1 beta secretion by THP-1 macrophages infected with E. faecalis. The results showed that E. faecalis infection activated caspase-1 and the NLRP3 inflammasome to induce IL-1 beta secretion and inflammatory cell death (pyroptosis). Furthermore, the activation and expression of NLRP3 induced by E. faecalis required P2X7R and K+ efflux, suggesting NLRP3 may be a potential target for treatment and prevention of persistent periodontitis caused by E. faecalis.

MICROBIAL PATHOGENESIS (2021)

Article Health Care Sciences & Services

Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice

Hung-Jen Shih et al.

Summary: The novel peptide KCF18 can simultaneously inhibit TNF-alpha, IL-1 beta, and IL-6, leading to significantly lower levels of liver injury in mice with endotoxemia.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Oncology

Interleukin-6: A Masterplayer in the Cytokine Network

Peter Uciechowski et al.

ONCOLOGY (2020)

Article Critical Care Medicine

Pathophysiology of Septic Shock

James A. Russell et al.

CRITICAL CARE CLINICS (2018)

Article Multidisciplinary Sciences

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse

Marilee J. Wick et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

Review Pharmacology & Pharmacy

Anti-TNFα therapy in inflammatory lung diseases

Rama Malaviya et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Multidisciplinary Sciences

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Stephanie A. Conos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Veterinary Sciences

Lipopolysaccharide-induced inflammatory liver injury in mice

K. Hamesch et al.

LABORATORY ANIMALS (2015)

Article Immunology

Anti-TNF therapy: past, present and future

Claudia Monaco et al.

INTERNATIONAL IMMUNOLOGY (2015)

Article Medicine, General & Internal

Anti-TNF-α therapy for patients with sepsis: a systematic meta-analysis

S. Lv et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2014)

Review Immunology

Interleukin-1β in innate inflammation, autophagy and immunity

Leo A. B. Joosten et al.

SEMINARS IN IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Going up in flames: necrotic cell injury and inflammatory diseases

Sreerupa Challa et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Biotechnology & Applied Microbiology

Tumor Necrosis Factor-a Signaling in Macrophages

Narayanan Parameswaran et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2010)

Review Biochemistry & Molecular Biology

Inflammatory markers in SIRS, sepsis and septic shock

I. Herzum et al.

CURRENT MEDICINAL CHEMISTRY (2008)

Article Critical Care Medicine

Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis

Fernando A. Bozza et al.

CRITICAL CARE (2007)

Review Biochemistry & Molecular Biology

TRAIL and apoptosis induction by TNF-family death receptors

SL Wang et al.

ONCOGENE (2003)

Article Cell Biology

Death Receptor Activation Complexes It Takes Two to Activate TNF Receptor 1

M. Saeed Sheikh et al.

CELL CYCLE (2003)