Journal
PHARMACEUTICALS
Volume 15, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ph15050514
Keywords
quaternary ammonium compounds; antiseptics; disinfectants; biocides; pyridinium salts; antibacterial activity; antibiofilm activity; bacterial resistance
Categories
Funding
- Russian Science Foundation (RSF) [17-73-20260]
Ask authors/readers for more resources
The study demonstrates that quaternary ammonium compounds based on pyridine structures with aromatic spacers have high antibacterial activity against clinically significant microorganisms, show synergistic effects in antiseptic formulations, and exhibit good antibiofilm properties.
This work is devoted to the investigation of biocidal properties of quaternary ammonium compounds (QACs) based on pyridine structures with aromatic spacers, and their widely known analogs, against clinically significant microorganisms. This study is focused on investigating their antimicrobial activity (minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs)), antibiofilm properties (minimum biofilm inhibitory concentrations (MBICs) and minimum biofilm eradication concentrations (MBECs)), synergetic effect with different alcohols in antiseptic formulations, and bacterial resistance development. It was shown that all combined analogue preparations had a higher level of antibacterial activity against the tested bacterial strains, with a 16- to 32-fold reduction in MICs and MBCs compared to previously used antiseptic preparations. Moreover, hit-QACs demonstrated a stable effect against Gram-negative E. coli, K. pneumoniae, and A. baumannii within a month of incubation. Overall results indicated a high level of antibacterial activity of pyridine-based QACs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available