4.6 Article

Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice

Related references

Note: Only part of the references are listed.
Article Neurosciences

Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors

Gleice K. Silva-Cardoso et al.

Summary: The study evaluated the effects of CBD on neuropathic pain, finding that low doses of CBD could reverse mechanical and thermal allodynia caused by pain and reduce anxious behaviors. The results suggest the potential benefits of CBD for treating chronic pain and associated conditions such as anxiety.

NEUROPHARMACOLOGY (2021)

Article Neurosciences

Blockade of GPR55 in dorsal periaqueductal gray produces anxiety-like behaviors and evocates defensive aggressive responses in alcohol-pre-exposed rats

Priscila Vazquez-Leon et al.

Summary: The study found that blocking GPR55 in the periaqueductal gray is associated with anxiety-like behaviors, defensive aggressive behaviors, and increased alcohol intake, while LPI in the same area produced anxiolytic effects but did not prevent alcohol consumption.

NEUROSCIENCE LETTERS (2021)

Article Neurosciences

Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder

Claire Alexander et al.

Summary: CBD acts by modulating 5-HT release from the dorsal raphe nucleus (DRN) to the amygdala and releasing anandamide onto amygdala inputs, reducing hyperactivity and normalizing signaling between the medial prefrontal cortex (mPFC) and amygdala. This mechanism leads to fear extinction and improved stress coping in PTSD patients.

IBRO NEUROSCIENCE REPORTS (2021)

Article Neurosciences

Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT1A and CB1 receptors

R. B. Malvestio et al.

Summary: The study found that the PrL cortex has antidepressant and analgesic effects with cannabidiol (CBD) in Wistar rats with chronic constriction injury. Blocking of CB1 and 5-HT1A receptors in the PrL cortex attenuated the effects of CBD, suggesting their involvement in the mechanism of action.

BRAIN RESEARCH BULLETIN (2021)

Article Clinical Neurology

CB1 and CB2 receptors in the bed nucleus of the stria terminalis differently modulate anxiety-like behaviors in rats

Lucas Gomes-de-Souza et al.

Summary: This study found the presence of CB1 and CB2 receptors in the BNST and their involvement in the control of anxiety-like behaviors. Activation of CB1 receptors inhibited anxiety responses, while CB2 receptors reduced exploratory behaviors in response to anxiety-inducing situations.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

Article Pharmacology & Pharmacy

Cannabidiol and Sertraline Regulate Behavioral and Brain Gene Expression Alterations in an Animal Model of PTSD

Ani Gasparyan et al.

Summary: The study demonstrated the significant therapeutic effects of combined treatment with CBD and STR on fear-related memory and anxiety-like behaviors in an animal model of PTSD, indicating the normalization of gene expression alterations in this model.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Gender differences in the effects of cannabidiol on ethanol binge drinking in mice

Adrian Viudez-Martinez et al.

ADDICTION BIOLOGY (2020)

Review Psychiatry

Endocannabinoid System Components as Potential Biomarkers in Psychiatry

Francisco Navarrete et al.

FRONTIERS IN PSYCHIATRY (2020)

Review Biochemistry & Molecular Biology

Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

Maria S. Garcia-Gutierrez et al.

BIOMOLECULES (2020)

Review Chemistry, Multidisciplinary

Integrating endocannabinoid signaling in the regulation of anxiety and depression

An-qi Yin et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Chemistry, Multidisciplinary

Cannabidiol does not display drug abuse potential in mice behavior

Adrian Viudez-Martinez et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Psychology, Biological

Effects of cannabidiol in males and females in two different rat models of depression

Liat Shbiro et al.

PHYSIOLOGY & BEHAVIOR (2019)

Review Neurosciences

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

Manoela V. Fogaca et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Article Behavioral Sciences

Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism

Jerzy Zieba et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2019)

Article Clinical Neurology

Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors

Alice Hartmann et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)

Article Pharmacology & Pharmacy

Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal

Francisco Navarrete et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Psychiatry

CHALLENGES OF TREATMENT-RESISTANT DEPRESSION

James Paul Pandarakalam

PSYCHIATRIA DANUBINA (2018)

Article Psychology, Clinical

WHO World Mental Health Surveys International College Student Project: Prevalence and Distribution of Mental Disorders

Randy P. Auerbach et al.

JOURNAL OF ABNORMAL PSYCHOLOGY (2018)

Article Biochemistry & Molecular Biology

Cannabidiol reduces ethanol consumption, motivation and relapse in mice

Adrian Viudez-Martinez et al.

ADDICTION BIOLOGY (2018)

Review Pharmacology & Pharmacy

The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABAA receptors

T. Bakas et al.

PHARMACOLOGICAL RESEARCH (2017)

Review Pharmacology & Pharmacy

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Psychology, Clinical

Assessing the Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression

Bradley Gaynes

JOURNAL OF CLINICAL PSYCHIATRY (2016)

Review Oncology

Endocannabinoid system: Role in depression, reward and pain control (Review)

Wen-Juan Huang et al.

MOLECULAR MEDICINE REPORTS (2016)

Article Neurosciences

Prohedonic Effect of Cannabidiol in a Rat Model of Depression

Gal Shoval et al.

NEUROPSYCHOBIOLOGY (2016)

Article Clinical Neurology

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Angelica Pupin Schiavon et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

Article Pharmacology & Pharmacy

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

R. B. Laprairie et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Article Pharmacology & Pharmacy

Central administration of GPR55 receptor agonist and antagonist modulates anxiety-related behaviors in rats

Abbasali Rahimi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2015)

Review Clinical Neurology

Cannabidiol as a Potential Treatment for Anxiety Disorders

Esther M. Blessing et al.

NEUROTHERAPEUTICS (2015)

Review Clinical Neurology

Molecular Targets of Cannabidiol in Neurological Disorders

Clementino Ibeas Bih et al.

NEUROTHERAPEUTICS (2015)

Article Pharmacology & Pharmacy

Regulatory role of the cannabinoid CB2 receptor in stress- induced neuroinflammation in mice

S. Zoppi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Relationships between serotonergic and cannabinoid system in depressive-like behavior: a PET study with [11C]-DASB

Aurelijus Burokas et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Behavioral Sciences

Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors

Fabricio H. Do Monte et al.

BEHAVIOURAL BRAIN RESEARCH (2013)

Article Clinical Neurology

Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

Valeria Almeida et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

Article Pharmacology & Pharmacy

Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors

Maria S. Garcia-Gutierrez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Pharmacology & Pharmacy

Pregabalin- and topiramate-mediated regulation of cognitive and motor impulsivity in DBA/2 mice

Francisco Navarrete et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Biology

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

Alline Cristina Campos et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2012)

Article Behavioral Sciences

Antidepressant-like properties of α2-containing GABAA receptors

Isabel Vollenweider et al.

BEHAVIOURAL BRAIN RESEARCH (2011)

Article Clinical Neurology

Decreased GABA(A) and GABA(B) receptor functional activity in cannabinoid CB1 receptor knockout mice

Leyre Urigueen et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2011)

Article Neurosciences

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

Antonio Ortega-Alvaro et al.

NEUROPSYCHOPHARMACOLOGY (2011)

Article Behavioral Sciences

Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors

Plinio C. Casarotto et al.

BEHAVIOURAL PHARMACOLOGY (2010)

Article Pharmacology & Pharmacy

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

T. V. Zanelati et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Pharmacology & Pharmacy

Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors

M. S. Garcia-Gutierrez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Behavioral Sciences

Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats

Grazyna Biala et al.

BEHAVIOURAL BRAIN RESEARCH (2009)

Review Pharmacology & Pharmacy

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

Angelo A. Izzo et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Article Pharmacology & Pharmacy

The orphan receptor GPR55 is a novel cannabinoid receptor

E. Ryberg et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Pharmacology & Pharmacy

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

A. Thomas et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Review Clinical Neurology

Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test

Fabricio A. Moreira et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2006)

Article Pharmacology & Pharmacy

Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors

M Kathmann et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

Agonistic properties of cannabidiol at 5-HT1a receptors

EB Russo et al.

NEUROCHEMICAL RESEARCH (2005)

Article Neurosciences

Diagnosis and definition of treatment-resistant depression

M Fava

BIOLOGICAL PSYCHIATRY (2003)

Article Biochemistry & Molecular Biology

Anandamide hydrolysis: a new target for anti-anxiety drugs?

S Gaetani et al.

TRENDS IN MOLECULAR MEDICINE (2003)

Article Neurosciences

The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety

J Haller et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2002)

Article Neurosciences

Involvement of CB1 cannabinoid receptors in emotional behaviour

M Martin et al.

PSYCHOPHARMACOLOGY (2002)