Journal
PHARMACEUTICALS
Volume 15, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ph15040487
Keywords
carbon dots; antimicrobial; light activation; photodynamic effect; reactive oxygen species
Categories
Funding
- National Natural Science Foundation of China [52172033, 51772001]
- Anhui Province Key Research and Development Plan Project International Science and Technology Cooperation Special Project [202004b11020015]
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The misuse of antibiotics leads to increased antimicrobial resistance, necessitating the development of novel antibacterial agents. Photodynamic antimicrobial chemotherapy (PACT) is gaining popularity due to its advantages. Carbon dots (CDs), as green and cost-effective photosensitizers, offer an alternative option for PACT. This review discusses the synthesis methods and recent progress of antibacterial CDs in photodynamic sterilization, aiming to maximize their bactericidal impact.
The misuse of many types of broad-spectrum antibiotics leads to increased antimicrobial resistance. As a result, the development of a novel antibacterial agent is essential. Photodynamic antimicrobial chemotherapy (PACT) is becoming more popular due to its advantages in eliminating drug-resistant strains and providing broad-spectrum antibacterial resistance. Carbon dots (CDs), zero-dimensional nanomaterials with diameters smaller than 10 nm, offer a green and cost-effective alternative to PACT photosensitizers. This article reviewed the synthesis methods of antibacterial CDs as well as the recent progress of CDs and their nanocomposites in photodynamic sterilization, focusing on maximizing the bactericidal impact of CDs photosensitizers. This review establishes the base for future CDs development in the PACT field.
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