4.6 Article

Mapping the Lipids of Skin Sebaceous Glands and Hair Follicles by High Spatial Resolution MALDI Imaging Mass Spectrometry

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Summary: Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is a valuable tool in lipid research due to its speed, sensitivity, and ability to tolerate impurities. This article discusses the methodology, ion-forming processes, and characteristics of different lipid classes in MALDI MS, with a focus on glycerophospholipids. The article also highlights the progress made in the last decade, particularly in the quantitative aspects of MALDI MS. The careful choice of matrix and the combination of MALDI MS with thin-layer chromatography (TLC) are emphasized as important factors for successful lipid detection.

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