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Analysis of synaptotagmin, SV2, and Rab3 expression in cortical glutamatergic and GABAergic axon terminals
Luca Bragina et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2012)
The Synaptic Vesicle Glycoprotein 2A Ligand Levetiracetam Inhibits Presynaptic Ca2+ Channels through an Intracellular Pathway
Christian Vogl et al.
MOLECULAR PHARMACOLOGY (2012)
Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding
Jiye Shi et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2011)
Levetiracetam in brain ischemia: Clinical implications in neuroprotection and prevention of post-stroke epilepsy
Vincenzo Belcastro et al.
BRAIN & DEVELOPMENT (2011)
Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGF beta 1 regulation
Martin N. Stienen et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties
Michel Gillard et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam
Anna L. Meehan et al.
JOURNAL OF NEUROPHYSIOLOGY (2011)
Levetiracetam exhibits protective properties on rat Schwann cells in vitro
Mark Stettner et al.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2011)
The role of inflammation in epilepsy
Annamaria Vezzani et al.
NATURE REVIEWS NEUROLOGY (2011)
Levetiracetam is Associated with Improved Cognitive Outcome for Patients with Intracranial Hemorrhage
Scott Taylor et al.
NEUROCRITICAL CARE (2011)
Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma
M. de Groot et al.
NEUROLOGY (2011)
Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A
Amy Nowack et al.
PLOS ONE (2011)
Levetiracetam in the treatment of epilepsy
Bassel Abou-Khalil
Neuropsychiatric Disease and Treatment (2011)
Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats
Kenneth V. Christensen et al.
BMC NEUROSCIENCE (2010)
Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus
Yuki Sugaya et al.
BRAIN RESEARCH (2010)
The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action
A. Micov et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression
Anne Frycia et al.
CHEMMEDCHEM (2010)
Effects of Valproate, Carbamazepine, and Levetiracetam on the Antioxidant and Oxidant Systems in Epileptic Patients and Their Clinical Importance
Asuman Orhan Varoglu et al.
CLINICAL NEUROPHARMACOLOGY (2010)
Piracetam and Piracetam-Like Drugs From Basic Science to Novel Clinical Applications to CNS Disorders
Andrei G. Malykh et al.
DRUGS (2010)
Alterations of intracerebral γ-aminobutyric acid (GABA) levels by titration with levetiracetam in patients with focal epilepsies
Marc T. Doelken et al.
EPILEPSIA (2010)
Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin
Bjornar Hassel et al.
EPILEPSIA (2010)
Levetiracetam: a comprehensive review
Amy Z. Crepeau et al.
EXPERT REVIEW OF NEUROTHERAPEUTICS (2010)
Efficacy of Tricyclic Antidepressant Therapy in Adults With Cyclic Vomiting Syndrome A Two-year Follow-up Study
Reza A. Hejazi et al.
JOURNAL OF CLINICAL GASTROENTEROLOGY (2010)
Quantitative Comparison of Glutamatergic and GABAergic Synaptic Vesicles Unveils Selectivity for Few Proteins Including MAL2, a Novel Synaptic Vesicle Protein
Mads Gronborg et al.
JOURNAL OF NEUROSCIENCE (2010)
Cotrafficking of SV2 and Synaptotagmin at the Synapse
Jia Yao et al.
JOURNAL OF NEUROSCIENCE (2010)
Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: Behavioral, physiological and histological studies
Yi Zheng et al.
NEUROPHARMACOLOGY (2010)
Levetiracetam inhibits interleukin-1β inflammatory responses in the hippocampus and piriform cortex of epileptic rats
Ji-Eun Kim et al.
NEUROSCIENCE LETTERS (2010)
Levetiracetam inhibits kindling-induced synaptic potentiation in the dentate gyrus of freely moving rats
Yuki Sugaya et al.
NEUROSCIENCE RESEARCH (2010)
Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research
Wolfgang Loescher et al.
PHARMACOLOGICAL REVIEWS (2010)
Efficacy and Safety of Levetiracetam for Outpatient Alcohol Detoxification
C. A. Mueller et al.
PHARMACOPSYCHIATRY (2010)
Enhancement of GABAA-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy
Manuela Mazzuferi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The effects of levetiracetam on urinary 15f-2t-isoprostane levels in epileptic patients
Hilmi Ozden et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2010)
Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures
Joseph Safdieh et al.
Neuropsychiatric Disease and Treatment (2010)
Levetiracetam for managing neurologic and psychiatric disorders
Muhammad U. Farooq et al.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2009)
Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling
Yukihiro Ohno et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus
Chun-Yao Lee et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures
Jesus Eric Pina-Garza et al.
EPILEPSIA (2009)
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam
Rafal M. Kaminski et al.
EPILEPSIA (2009)
Effects of levetiracetam on chronic pain in multiple sclerosis: results of a pilot, randomized, placebo-controlled study
S. Rossi et al.
EUROPEAN JOURNAL OF NEUROLOGY (2009)
SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis
Wen-Pin Chang et al.
JOURNAL OF NEUROSCIENCE (2009)
Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study
Jakob Christensen et al.
LANCET (2009)
Effectiveness of Levetiracetam in the Treatment of Lumbar Radiculopathy: An Open-Label Prospective Cohort Study
Maged S. Hamza et al.
PM&R (2009)
Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats
Doru-Georg Margineanu et al.
BRAIN RESEARCH BULLETIN (2008)
Brivaracetam: a rational drug discovery success story
M. A. Rogawski
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Treatment of juvenile myoclonic epilepsy
Stephane Auvin
CNS NEUROSCIENCE & THERAPEUTICS (2008)
Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model
Lyudmila V. Vinogradova et al.
EPILEPSIA (2008)
Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes
Elena A. Matveeva et al.
EPILEPSIA (2008)
Development of tolerance to levetiracetam in rats with chronic epilepsy
Erwin A. van Vliet et al.
EPILEPSIA (2008)
Levetiracetam monotherapy for late poststroke seizures in the elderly
Gulnihal Kutlu et al.
EPILEPSY & BEHAVIOR (2008)
Activity, tolerability and efficacy of levetiracetam on cerebellar symptoms in multiple sclerosis patients: a pilot kinematic study
C. Solaro et al.
EUROPEAN JOURNAL OF NEUROLOGY (2008)
Levetiracetam in patients with impulsive aggression: A double-blind, placebo-controlled trial
Jeffrey A. Mattes
JOURNAL OF CLINICAL PSYCHIATRY (2008)
Effects of levetiracetam on tardive dyskinesia: A randomized, double-blind, placebo-controlled study
Scott W. Woods et al.
JOURNAL OF CLINICAL PSYCHIATRY (2008)
Implications of antiinflammatory properties of the anticonvulsant drug levetiracetam in astrocytes
Aiden Haghikia et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery
Tracey A. Milligan et al.
NEUROLOGY (2008)
Levetiracetam Inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture
Nisha Nagarkatti et al.
NEUROSCIENCE LETTERS (2008)
Review: Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited
Rainer Surges et al.
Therapeutic Advances in Neurological Disorders (2008)
Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor:: Neurochemical, neurophysiological, and behavioral effects
Andrew K. Evans et al.
CNS DRUG REVIEWS (2007)
Prolonged exposure to levetiracetam reveals a presynaptic effect on neurotransmission
Xiao-Feng Yang et al.
EPILEPSIA (2007)
The Antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation
Eleonora Palma et al.
EPILEPSIA (2007)
Prophylactic treatment with levetiracetam after status epilepticus:: Lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats
Claudia Brandt et al.
NEUROPHARMACOLOGY (2007)
Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures
A. A. Oliveira et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2007)
Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam
Irene Carunchio et al.
EPILEPSIA (2007)
Zonisamide or levetiracetam for adults with cyclic vomiting syndrome: A case series
Ray E. Clouse et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2007)
Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy
Sanjay N. Rakhade et al.
EPILEPSIA (2007)
Levetiracetam in the prophylaxis of migraine with aura: A 6-month open-label study
Filippo Brighina et al.
CLINICAL NEUROPHARMACOLOGY (2006)
Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy
D Arion et al.
NEUROBIOLOGY OF DISEASE (2006)
Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia
C Costa et al.
STROKE (2006)
Levetiracetam: Antiepileptic properties and protective effects on mitochondrial dysfunction in experimental status epilepticus
JE Gibbs et al.
EPILEPSIA (2006)
Synaptic vesicle protein 2 enhances release probability at quiescent synapses
KL Custer et al.
JOURNAL OF NEUROSCIENCE (2006)
Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage
Haichen Wang et al.
NEUROCRITICAL CARE (2006)
Evaluation of levetiracetam effects on pilocarpine-induced seizures: Cholinergic muscarinic system involvement
AA Oliveira et al.
NEUROSCIENCE LETTERS (2005)
Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER)
HD Yan et al.
EPILEPSIA (2005)
Use of levetiracetarn to treat tics in children and adolescents with Tourette syndrome
Y Awaad et al.
MOVEMENT DISORDERS (2005)
SV2A and SV2C contain a unique synaptotagmin-binding site
AE Schivell et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
The antiepileptic drug levetiracetam decreases the inositol 1,4,5-trisphosphate-dependent [Ca2+]i increase induced by ATP and bradykinin in PC12 cells
M Cataldi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): Differentiation of levetiracetam from conventional antiepileptic drugs
C Ji-qun et al.
EPILEPSIA (2005)
Levetiracetam in the treatment of vascular chorea: a case report
M D'Amelio et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling:: implications for antiepileptogenic and mood-stabilizing properties
H Husum et al.
EPILEPSY & BEHAVIOR (2004)
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity
BM Kenda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Levetiracetam inhibits Na+-dependent Cl-/HCO3- exchange of adult hippocampal CA3 neurons from guinea-pigs
T Leniger et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Effects of levetiracetam on spike and wave discharges in WAG/Rij rats
BM Bouwman et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2004)
Intracellular calcium increase in epileptiform activity: Modulation by levetiracetam and lamotrigine
A Pisani et al.
EPILEPSIA (2004)
Modulation of IL-1 β gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury
H Marini et al.
EXPERIMENTAL NEUROLOGY (2004)
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
BA Lynch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Binding characteristics of [3H]ucb 30889 to levetiracetam binding sites in rat brain
M Gillard et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia
P Calabresi et al.
ANNALS OF NEUROLOGY (2003)
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy
H Klitgaard et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2003)
Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model
SC Stratton et al.
EPILEPSY RESEARCH (2003)
Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy
T Sander et al.
EPILEPSY RESEARCH (2002)
The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents
JM Rigo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Is epilepsy a progressive disorder?: Prospects for new therapeutic approaches in temporal-lobe epilepsy
A Pitkänen et al.
LANCET NEUROLOGY (2002)
Efficacy and safety of levetiracetam in children with partial seizures: An open-label trial
TA Glauser et al.
EPILEPSIA (2002)
Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy
M Glien et al.
EPILEPSIA (2002)
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs
F Gualtieri et al.
CURRENT PHARMACEUTICAL DESIGN (2002)
Selective blockade of N-type calcium channels by levetiracetam
EA Lukyanetz et al.
EPILEPSIA (2002)
A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy
HC Doheny et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Dose-response effect of levetiracetam 1000 and 2000 mg/day in partial epilepsy
P Boon et al.
EPILEPSY RESEARCH (2002)
Effect of levetiracetam in patients with epilepsy and interictal epileptiform discharges
S Stodieck et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2001)
SV2 modulates the size of the readily releasable pool of secretory vesicles
T Xu et al.
NATURE CELL BIOLOGY (2001)
A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain
X Tong et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Levetiracetam inhibits the high-voltage-activated Ca2+ current in pyramidal neurones of rat hippocampal slices
I Niespodziany et al.
NEUROSCIENCE LETTERS (2001)
Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia
E Hanon et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2001)
Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: A multicenter, double-blind, responder-selected study evaluating monotherapy
E Ben-Menachem et al.
EPILEPSIA (2000)
Levetiracetam for partial seizures - Results of a double-blind, randomized clinical trial
JJ Cereghino et al.
NEUROLOGY (2000)
Pharmacokinetic profile of levetiracetam: toward ideal characteristics
PN Patsalos
PHARMACOLOGY & THERAPEUTICS (2000)
Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures
SD Shorvon et al.
EPILEPSIA (2000)
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