4.7 Review

Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials

Journal

JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 5, Pages -

Publisher

MDPI
DOI: 10.3390/jpm12050840

Keywords

DIPG; high grade gliomas; childhood gliomas; H3 K27M

Funding

  1. NIH [K08NS092895]

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Diffuse intrinsic pontine glioma (DIPG) is a type of brainstem tumor that occurs primarily in children and is characterized by high infiltrative capacity and multiple genetic mutations. Advances in molecular understanding, including the categorization of tumors with the H3 K27M mutation and the development of treatment options, have improved our knowledge of this disease.
Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms and the characteristic location on imaging. Histologically, these tumors are characterized by a heterogenous population of cells with multiple genetic mutations and high infiltrative capacity. The most common mutation seen in this group is a lysine to methionine point mutation seen at position 27 (K27M) within histone 3 (H3). Tumors with the H3 K27M mutation, are considered grade 4 and are now categorized within the H3 K27-altered diffuse midline glioma category by World Health Organization classification. Due to its critical location and aggressive nature, DIPG is resistant to the most eradicative treatment and is universally fatal; however, modern advances in the surgical techniques resulting in safe biopsy of the lesion have significantly improved our understanding of this disease at the molecular level. Genomic analysis has shown several mutations that play a role in the pathophysiology of the disease and can be targeted therapeutically. In this review, we will elaborate on DIPG from general aspects and the evolving molecular landscape. We will also review innovative therapeutic options that have been trialed along with new promising treatments on the horizon.

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