Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jpm12030415
Keywords
integrated score index; diastolic function; 2-dimensional echocardiography; tissue Doppler imaging; hypertension; elderly; coronary artery disease
Funding
- New Century Health Care Promotion Foundation [NCHCPF001]
- National Taiwan University Hospital Yun-Lin Branch [NTUHYL 110, X001]
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This 12-year study compared the longitudinal change in left ventricular diastolic dysfunction (LVDD) among healthy elderly, coronary artery disease (CAD), and hypertension (HTN) patients. The study found that under aggressive treatment, diastolic function was relatively preserved in HTN subjects with aging in comparison with elderly and CAD subjects.
Background: This 12-year study aimed to compare the longitudinal change in left ventricular diastolic dysfunction (LVDD) between healthy elderly, coronary artery disease (CAD), and hypertension (HTN) patients. Methods: From 2008 to 2020, 1476 patients were included, and 3181 echocardiography examinations were conducted. Finally, 130 participants (36 healthy elderly (79.39 +/- 9.51 years old), 51 with CAD (68.31 +/- 12.09 years old), and 43 with HTN (68.31 +/- 12.09 years old)) with more than a 10-year follow-up period were included in the final analysis. Results: The change in diastolic function was different among these subjects according to the integrated score index (elderly vs. HTN, p = 0.01; CAD vs. HTN, p = 0.01), septal E/e' ratio (elderly vs. HTN, p < 0.001; CAD vs. HTN, p = 0.01), lateral E/e' ratio (elderly vs. HTN, p < 0.001; CAD vs. HTN, p < 0.001), and NYHA functional class (elderly vs. HTN, p = 0.03; CAD vs. HTN, p < 0.001). Additionally, per one-year increase in age, the integrated score index increased 0.2 in the healthy elderly, 0.15 in the CAD, and 0.06 in the HTN patients (all p < 0.05). Conclusion: Under aggressive treatment, diastolic function was relatively preserved in HTN subjects with aging in comparison with elderly and CAD subjects.
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