4.7 Review

Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer

Related references

Note: Only part of the references are listed.
Editorial Material Oncology

Editorial: Molecular Biomarkers for Gastric Cancer

Xinqiang Hong et al.

FRONTIERS IN ONCOLOGY (2022)

Article Gastroenterology & Hepatology

Mist1+gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice

Henrik Nienhuser et al.

Summary: The study revealed that gastric Mist1+ isthmus cells are activated in response to injury and inflammation, playing a crucial role in the regeneration of gastric glands through the Wnt5a pathway.
Article Gastroenterology & Hepatology

Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair

Junichi Matsuo et al.

Summary: The study identified Iqgap3 as a highly specific marker of proliferating isthmus stem cells in the stomach, essential for maintaining stem potential and promoting strong proliferation in coordination with the Ras pathway. The robust induction of Iqgap3 expression following tissue damage suggests an active role in tissue regeneration. The upregulation of IQGAP3 in gastric cancer indicates its importance in cancer cell proliferation.
Letter Biotechnology & Applied Microbiology

The Organoid Cell Atlas

Christoph Bock et al.

NATURE BIOTECHNOLOGY (2021)

Review Oncology

Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis

Mahdieh Razmi et al.

Summary: The meta-analysis revealed that overexpression of cancer stem cell (CSC) markers is associated with worse outcomes in gastric cancer patients, including TNM stage, lymph node metastasis, survival rate, disease-specific survival, and disease-free survival. Specific CSC markers such as Gli-1, Oct-4, CD44, CD44V6, and CD133 showed stronger correlations with clinical outcomes and reduced survival compared to others like Lgr-5, Nanog, and sonic hedgehog.

CANCER CELL INTERNATIONAL (2021)

Article Cell Biology

A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers

A. Fatehullah et al.

Summary: Researchers developed transgenic and orthotopic mouse models to recapitulate advanced human gastric cancer, uncovering a mechanistic role for Lgr5(+) stem-like cells in promoting disease initiation and progression. These models accurately recapitulate advanced human gastric cancer characteristics and demonstrate the critical role of tumor-resident Lgr5(+) stem-like cells.

NATURE CELL BIOLOGY (2021)

Review Cell & Tissue Engineering

Stem cells and origins of cancer in the upper gastrointestinal tract

Yoku Hayakawa et al.

Summary: In this article, we discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer. The interactions between the stromal niche and gastroesophageal stem cells play a vital role in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis. New approaches are being developed to better study gastroesophageal stem cells and advance the field.

CELL STEM CELL (2021)

Article Oncology

The clinical and prognostic significance of LGR5 in GC: A meta-analysis of IHC assay and bioinformatics analysis

Fei Guo et al.

Summary: This study found that the expression of LGR5 in gastric cancer is associated with tumor type and grade, with a significant correlation in intestinal type. Furthermore, LGR5 may serve as a potential prognostic factor for survival prediction in gastric cancer.

NEOPLASMA (2021)

Review Biochemistry & Molecular Biology

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

Sungjin Min et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

AQP5 enriches for stem cells and cancer origins in the distal stomach

Si Hui Tan et al.

NATURE (2020)

Article Cell & Tissue Engineering

Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis

Wenju Chang et al.

CELL STEM CELL (2020)

Article Medicine, General & Internal

Effect of gastric cancer stem cell on gastric cancer invasion, migration and angiogenesis

Zhipeng Zhu et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Gastroenterology & Hepatology

Hypergastrinemia Expands Gastric ECL Cells Through CCK2R(+) Progenitor Cells via ERK Activation

Weiwei Sheng et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Oncology

Bmi1 marks gastric stem cells located in the isthmus in mice

Takuto Yoshioka et al.

JOURNAL OF PATHOLOGY (2019)

Article Cell Biology

R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach

Michael Sigal et al.

NATURE CELL BIOLOGY (2019)

Article Cell & Tissue Engineering

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells

Seungmin Han et al.

CELL STEM CELL (2019)

Article Biochemical Research Methods

Generation of human antral and fundic gastric organoids from pluripotent stem cells

Taylor R. Broda et al.

NATURE PROTOCOLS (2019)

Review Cell Biology

Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury

Yu-Qing Lv et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Oncology

Oct4 expression in gastric carcinoma: association with tumor proliferation, angiogenesis and survival

Dina M. El-Guindy et al.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2019)

Article Gastroenterology & Hepatology

Mature gastric chief cells are not required for the development of metaplasia

Hiroto Kinoshita et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Gastroenterology & Hepatology

Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice

Junichi Matsuo et al.

GASTROENTEROLOGY (2017)

Article Multidisciplinary Sciences

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

Michael Sigal et al.

NATURE (2017)

Review Gastroenterology & Hepatology

Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling

Andrea Todisco

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells

Yiseul Choi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Pharmacology & Pharmacy

Differential expression of two genes Oct-4 and MUC5AC associates with poor outcome in patients with gastric cancer

Milad Javanbakht et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2017)

Review Gastroenterology & Hepatology

Dclk1-expressing tuft cells: critical modulators of the intestinal niche?

Moritz Middelhoff et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Article Gastroenterology & Hepatology

NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus

Elise S. Demitrack et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Review Developmental Biology

Stomach development, stem cells and disease

Tae-Hee Kim et al.

DEVELOPMENT (2016)

Review Neurosciences

Notch regulation of gastrointestinal stem cells

Elise S. Demitrack et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Article Cell Biology

Sox2 Suppresses Gastric Tumorigenesis in Mice

Abby Sarkar et al.

CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

Daniel L. Worthley et al.

Review Gastroenterology & Hepatology

Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma

Patrick Tan et al.

GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

Sina Bartfeld et al.

GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis

Yoku Hayakawa et al.

Article Multidisciplinary Sciences

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Kyle W. McCracken et al.

NATURE (2014)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

Article Multidisciplinary Sciences

Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors

Nobu Oshima et al.

PLOS ONE (2014)

Article Cell Biology

Denervation suppresses gastric tumorigenesis

Chun-Mei Zhao et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Biochemistry & Molecular Biology

Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche.

Takahito Katano et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Gastroenterology & Hepatology

Gastric Cancer Pathology and Underlying Molecular Mechanisms

Heike I. Grabsch et al.

DIGESTIVE SURGERY (2013)

Article Biochemistry & Molecular Biology

Identification of cancer stem cells in vincristine preconditioned SGC7901 gastric cancer cell line

Zengfu Xue et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2012)

Article Surgery

Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma

Junko Matsuoka et al.

JOURNAL OF SURGICAL RESEARCH (2012)

Article Biochemical Research Methods

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

Jiri Kalabis et al.

NATURE PROTOCOLS (2012)

Article Medical Laboratory Technology

New paradigms in translational science research in cancer biomarkers

Paul D. Wagner et al.

TRANSLATIONAL RESEARCH (2012)

Article Biochemistry & Molecular Biology

The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma

Dong-Dong Yang et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2011)

Article Cell & Tissue Engineering

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

Katrin Arnold et al.

CELL STEM CELL (2011)

Review Oncology

Boundaries, junctions and transitions in the gastrointestinal tract

Adrianna K. San Roman et al.

EXPERIMENTAL CELL RESEARCH (2011)

Review Gastroenterology & Hepatology

Gastric Epithelial Stem Cells

Jason C. Mills et al.

GASTROENTEROLOGY (2011)

Editorial Material Public, Environmental & Occupational Health

Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses

Andreas Stang

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2010)

Article Gastroenterology & Hepatology

Mature Chief Cells Are Cryptic Progenitors for Metaplasia in the Stomach

Ki Taek Nam et al.

GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

SOX2 in Gastric Carcinoma, but not Hath1, is Related to Patients' Clinicopathological Features and Prognosis

Xin Zhang et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2010)

Article Biochemistry & Molecular Biology

BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer

Xiao-Wei Zhang et al.

MOLECULAR CANCER (2010)

Article Multidisciplinary Sciences

Defined factors induce reprogramming of gastrointestinal cancer cells

Norikatsu Miyoshi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

Rudolf Jaenisch et al.

Article Oncology

Bmi-1 expression predicts prognosis for patients with gastric carcinoma

Jian-Hua Liu et al.

JOURNAL OF SURGICAL ONCOLOGY (2008)

Article Gastroenterology & Hepatology

Multipotential stem cells in adult mouse gastric epithelium

M Bjerknes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)

Article Gastroenterology & Hepatology

Sonic hedgehog regulates gastric gland morphogenesis in man and mouse

GR van den Brink et al.

GASTROENTEROLOGY (2001)