Journal
ISCIENCE
Volume 25, Issue 4, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2022.104083
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Funding
- German Aerospace Center [D/572/67246870, D/572/67270080, D/572/67302614]
- European Union [720270, 785907, 945539]
- Hand Embodied (THE) (EU) [248587]
- Swedish Research Council
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By exploring the connectivity of spinal interneurons, it was found that their input connections form a continuum, contrary to the currently widespread notion of distinct classes of interneurons. This suggests a diversified physiological connectivity which likely requires a major component of circuitry learning, implying a more flexible functionality.
The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity of muscular, tendon, and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat in vivo, we could define mono-, di-, and trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum. Our data hence contrasts with the currently widespread notion of distinct classes of interneurons. We argue that this suggested diversified physiological connectivity, which likely requires a major component of circuitry learning, implies a more flexible functionality.
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