Journal
JOURNAL OF FUNGI
Volume 8, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/jof8050454
Keywords
Asteromyces cruciatus; marine fungi; secondary metabolites; polyketides; sortase A; chlore-containing metabolites; Staphylococcus aureus; antibacterial activity; biofilm formation
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Funding
- Russian Science Foundation [19-74-10014]
- Russian Science Foundation [19-74-10014] Funding Source: Russian Science Foundation
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Six new polyketides, acrucipentyns A-F, were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. The absolute configuration of acrucipentyn A was determined using modified Mosher's method and ROESY data analysis. Acrucipentyns A-E are the first examples of chlorine-containing asperpentyn-like compounds and exhibit antimicrobial activity.
Six new polyketides acrucipentyns A-F (1-6) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A-F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of Staphylococcus aureus and decreased LDH release from human keratinocytes HaCaT in S. aureus skin infection in an in vitro model.
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