Journal
BIOMEDICINES
Volume 10, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10051186
Keywords
Botryococcus terribilis; me-meijicoccene; C32 botryococcene; dermal papilla cells; hair growth
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Funding
- Japan Science and Technology Agency (JST) Program Open Innovation Platform with Enterprises, Research Institute and Academia (OPERA) [JPMJOP1832]
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This study evaluated the hair growth promoting effect of the green alga Botryococcus terribilis and discovered its ability to stimulate various pathways and genes, influence collagen and keratin synthesis, and reduce inflammation. Additionally, a novel compound was isolated and found to have promising effects on hair growth.
A person's quality of life can be adversely affected by hair loss. Microalgae are widely recognized for their abundance and rich functional components. Here, we evaluated the hair growth effect of a green alga, Botryococcus terribilis (B. terribilis), in vitro using hair follicle dermal papilla cells (HFDPCs). We isolated two types of cells from B. terribilis - green and orange cells, obtained from two different culture conditions. Microarray and real time-PCR results revealed that both cell types stimulated the expression of several pathways and genes associated with different aspect of the hair follicle cycle. Additionally, we demonstrated B. terribilis' effect on collagen and keratin synthesis and inflammation reduction. We successfully isolated a novel compound, methylated-meijicoccene (me-meijicoccene), and C32 botryococcene from B. terribilis to validate their promising effects. Our study revealed that treatment with the two compounds had no cytotoxic effect on HFDPCs and significantly enhanced the gene expression levels of hair growth markers at low concentrations. Our study provides the first evidence of the underlying hair growth promoting effect of B. terribilis and its novel compound, me-meijicoccene, and C32 botryococcene.
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