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The Role of the Metabolism of Zinc and Manganese Ions in Human Cancerogenesis

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MOLECULAR MEDICINE REPORTS (2016)

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Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

Daniel R. Ram et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity

Yitong Zhao et al.

TRAFFIC (2016)

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Decreased expression of SLC39A14 is associated with tumor aggressiveness and biochemical recurrence of human prostate cancer

Xiao-Ming Xu et al.

ONCOTARGETS AND THERAPY (2016)

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Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems

Amos Toren et al.

ONCOTARGET (2016)

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Analysis of Zinc-Exporters Expression in Prostate Cancer

Chandra K. Singh et al.

SCIENTIFIC REPORTS (2016)

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Manganese ions induce H2O2 generation at the ubiquinone binding site of mitochondrial complex II

Erik Bonke et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2015)

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Tumor-targeting novel manganese complex induces ROS-mediated apoptotic and autophagic cancer cell death

Jia Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

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Engineering an Effective Mn-Binding MRI Reporter Protein by Subcellular Targeting

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MAGNETIC RESONANCE IN MEDICINE (2015)

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The cytotoxic role of RREB1, ZIP3 zinc transporter, and zinc in human pancreatic adenocarcinoma

Renty B. Franklin et al.

CANCER BIOLOGY & THERAPY (2014)

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Fluorescent Sensors for Measuring Metal Ions in Living Systems

Kyle P. Carter et al.

CHEMICAL REVIEWS (2014)

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Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity

Ira Kukic et al.

JOURNAL OF CELL SCIENCE (2014)

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Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity

Asuncion Carmona et al.

METALLOMICS (2014)

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Correction: Combinatorial Recruitment of CREB, C/EBPβ and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation

Julian M. Rozenberg et al.

PLoS One (2014)

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Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis

Chunhua Wan et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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Cellular manganese content is developmentally regulated in human dopaminergic neurons

Kevin K. Kumar et al.

SCIENTIFIC REPORTS (2014)

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Development of the First Fluorescence Screening Assay for the SLC39A2 Zinc Transporter

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JOURNAL OF BIOMOLECULAR SCREENING (2014)

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Binding of a Third Metal Ion by the Human Phosphatases PP2C alpha and Wip1 Is Required for Phosphatase Activity

Kan Tanoue et al.

BIOCHEMISTRY (2013)

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Metallothionein 2A inhibits NF-κB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection

Yuanming Pan et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2013)

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The SLC30 family of zinc transporters - A review of current understanding of their biological and pathophysiological roles

Liping Huang et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

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Determination of the detectable concentration of manganese used in neuronal MEMRI and its effect on cortical neurons in vitro

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NEUROLOGICAL RESEARCH (2013)

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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SCIENCE (2013)

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

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CELL REPORTS (2013)

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The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer

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INTERNATIONAL JOURNAL OF CANCER (2012)

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ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Meta nation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study

Joseph A. Cotruvo et al.

METALLOMICS (2012)

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Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome

Jeeyon Jeong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Manganese regulates caspase-3 gene promoter activity by inducing Sp1 phosphorylation in PC12 cells

Atsuhiro Uchida et al.

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Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

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ANTIOXIDANTS & REDOX SIGNALING (2011)

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Alternative Splicing of SLC39A14 in Colorectal Cancer is Regulated by the Wnt Pathway

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MOLECULAR & CELLULAR PROTEOMICS (2011)

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Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice

Yuguang Zhao et al.

TOXICOLOGY LETTERS (2011)

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Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function

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CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genes

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Ras Responsive Element Binding Protein-1 (RREB-1) Down-Regulates hZIP1 Expression in Prostate Cancer Cells

Beatrice C. Milon et al.

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Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

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Zinc salts differentially modulate DNA damage in normal and cancer cells

Tomasz Sliwinski et al.

CELL BIOLOGY INTERNATIONAL (2009)

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Identification of the Zn2+ Binding Site and Mode of Operation of a Mammalian Zn2+ Transporter

Ehud Ohana et al.

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Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

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The case for manganese interaction with mitochondria

Thomas E. Gunter et al.

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Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

Carin Thomas et al.

REDOX REPORT (2009)

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Zinc binding ligands and cellular zinc trafficking: Apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1

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Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats - An electron spectroscopy imaging and electron energy-loss spectroscopy study

M. Morello et al.

NEUROTOXICOLOGY (2008)

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P38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death

B. El Mchichi et al.

CELL DEATH AND DIFFERENTIATION (2007)

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Zinc irreversibly damages major enzymes of energy production and antioxidant Defense prior to mitochondrial permeability transition

Irina G. Gazaryan et al.

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Zinc is a novel intracellular second messenger

Satoru Yamasaki et al.

JOURNAL OF CELL BIOLOGY (2007)

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Assessment of chelatable mitochondrial iron by using mitochondrion-selective fluorescent iron indicators with different iron-binding affinities

Ursula Rauen et al.

CHEMBIOCHEM (2007)

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Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth

Christine J. Weydert et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

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Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion

Stephanie L. Gantt et al.

BIOCHEMISTRY (2006)

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Counting the zinc-proteins encoded in the human genome

C Andreini et al.

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Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor

Rebecca A. Bozym et al.

ACS CHEMICAL BIOLOGY (2006)

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hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer

Renty B. Franklin et al.

MOLECULAR CANCER (2005)

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Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells

L Behrend et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

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Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer

LC Costello et al.

MITOCHONDRION (2005)

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Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion

QQ Wei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)

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Terminal oxidation and the effects of zinc in prostate versus liver mitochondria

LC Costello et al.

MITOCHONDRION (2004)

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

A Vannini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes

I Chang et al.

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Cell cycle regulation and p53 activation by protein phosphatase 2Cα

P Ofek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Direct effect of zinc on mitochondrial apoptogenesis in prostate cells

P Feng et al.

PROSTATE (2002)

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Mitochondrial sequestration and Ca2+-dependent release of cytosolic Zn2+ loads in cortical neurons

SL Sensi et al.

NEUROBIOLOGY OF DISEASE (2002)

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Measuring zinc in living cells. A new generation of sensitive and selective fluorescent probes

KR Gee et al.

CELL CALCIUM (2002)

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Depletion of intracellular glutathione mediates zinc-induced cell death in rat primary astrocytes

JR Ryu et al.

EXPERIMENTAL BRAIN RESEARCH (2002)

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Differential cytotoxicity of Mn(II) and Mn(III): Special reference mitochondrial [Fe-S] containing enzymes

JY Chen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2001)

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Zinc-mediated regulation of caspases activity: dose-dependent inhibition or activation of caspase-3 in the human Burkitt lymphoma B cells (Ramos)

N Schrantz et al.

CELL DEATH AND DIFFERENTIATION (2001)

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