Journal
BIOMEDICINES
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10040893
Keywords
miRNA; psoriatic arthritis; rheumatoid arthritis; ankylosing spondylitis; inflammation; lipids; biomarkers; rheumatic diseases; lipid profile
Categories
Funding
- National Institute of Geriatrics, Rheumatology, and Rehabilitation from the Polish Ministry of Education and Science
- National Science Centre, Poland [2018/30/E/NZ5/00104, 2015/17/D/NZ5/02219]
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This study investigates the associations between miR signatures and cytokines, serum lipids, and disease activity in patients with PsA, AS, and RA. The results show the superiority of miR expressions in distinguishing between RA, PsA, and AS, and a unique regulatory pathway in PsA.
This study aimed to investigate the associations of microRNA (miRs) signatures with cytokines, serum lipids, and disease activity in patients with psoriatic arthritis (PsA), ankylosing spondylitis (AS), and rheumatoid arthritis (RA). In total, 65 patients (PsA n = 25, AS n = 25, RA n = 15) and 25 healthy controls (HC) were enrolled into the study. The expression of miR-223-5p, miR-92b-3p, miR-485-3p, miR-10b-5p, let-7d-5p, miR-26a-2-3p, miR-146b-3p, and cytokines levels were measured in sera. DIANA-mirPath analysis was used to predict pathways targeted by the dysregulated miRs. Disease activity scores were calculated. Lipid profile, uric acid, glucose level, and C-reactive protein (CRP) concentrations were determined in the blood. Based on lipid profiles, the PsA group had hypertriglyceridaemia, and RA patients revealed mixed dyslipidaemia, while in AS, no specific changes were found. miR expression analysis revealed upregulation of miR-26a-2-3p and miR-10b-5p in PsA, miR-485-3p in AS, and let-7d-5p in RA. Several correlations between disease activity indexes, metabolites levels, and expression of miRs were observed in PsA, RA, and AS patients. Finally, in ROC analysis, miR-26a-2-3p/miR-485-3p, and let-7d-5p/miR-146b-3p tandems revealed high sensitivity and specificity in distinguishing between PsA, AS, and RA. Our study illustrates the superiority of miR expressions in distinguishing between RA, PsA, and AS. In PsA, a unique regulatory pathway exists through miR-26a-2-3p, miR-223-5p, miR-10b-5p, and miR-92b-3p that converges proatherogenic metabolism and disease activity.
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