Journal
BIOMEDICINES
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10040754
Keywords
COVID-19; lipoprotein; HDL; proteomics; CER-001; case-report; sepsis; cytokines; inflammation
Categories
Funding
- POE FEDER [RE20201437, RE0027601]
- EU-Region Reunion-French State national counterpart
- Universite de La Reunion (COVID-19 emergency seed funding)
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This study investigated the use of recombinant HDL particles in a severe COVID-19 patient. The results showed that recombinant HDL increased ApoA1 abundance, increased the proportion of large HDL particles, and decreased the abundance of inflammatory proteins. Levels of inflammatory markers and cytokines also decreased during recombinant HDL infusion. Therefore, recombinant HDL infusion may be a potential therapeutic strategy for COVID-19 patients.
High-density lipoproteins (HDLs) have multiple endothelioprotective properties. During SARS-CoV-2 infection, HDL-cholesterol (HDL-C) concentration is markedly reduced, and studies have described severe impairment of the functionality of HDL particles. Here, we report a multi-omic investigation of the first administration of recombinant HDL (rHDL) particles in a severe COVID-19 patient in an intensive care unit. Plasma ApoA1 increased and HDL-C decreased after each recombinant HDL injection, suggesting that these particles were functional in terms of reverse cholesterol transport. The proportion of large HDL particles also increased after injection of recombinant HDL. Shotgun proteomics performed on HDLs isolated by ultracentrifugation indicated that ApoA1 was more abundant after injections whereas most of the pro-inflammatory proteins identified were less abundant. Assessment of Serum amyloid A-1, inflammatory markers, and cytokines showed a significant decrease for most of them during recombinant HDL infusion. Our results suggest that recombinant HDL infusion is feasible and a potential therapeutic strategy to be explored in COVID-19 patients.
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