Journal
BIOMEDICINES
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10030664
Keywords
cancer; DNA damage; copper; catechins; apoptosis
Categories
Funding
- Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia [AN000302]
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The possible roles of elevated endogenous copper levels in malignant cells are becoming increasingly understood. Tea catechins have the ability to mobilize endogenous copper and selectively damage cancer cells. Cellular copper transporters CTR1 and ATP7A play a role in the survival dynamics of malignant cells post-tea catechin exposure.
The possible roles of elevated endogenous copper levels in malignant cells are becoming increasingly understood at a greater depth. Our laboratory has previously demonstrated that tea catechins have the ability to mobilize endogenous copper and undergo a Fenton-like reaction that can selectively damage cancer cells. In this communication, by using a diverse panel of malignant cell lines, we demonstrate that the ability of the catechin family [(-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC), and (+)-catechin (C)] to induce apoptosis is dependent on their structure. We further confirm that reactive oxygen species (ROS) are the terminal effectors causing copper-mediated DNA damage. Our studies demonstrate the role of cellular copper transporters CTR1 and ATP7A in the survival dynamics of malignant cells post-EGCG exposure. The results, when considered together with our previous studies, highlight the critical role that copper dynamics and mobilization plays in cancer cells and paves the way for a better understanding of catechins as nutraceutical supplements for malignancies.
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