4.7 Review

Application of double-negative T cells in haematological malignancies: recent progress and future directions

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Review Oncology

Side-effect management of chimeric antigen receptor (CAR) T-cell therapy

M-L Schubert et al.

Summary: CAR T-cell therapy targeting CD19-expressing B cells has shown promising results in treating refractory and/or relapsed B-cell malignancies, but also presents challenges such as cytokine release syndrome and neurotoxicity syndrome. Optimal management strategies for the side-effects associated with CAR T-cell therapy are crucial as it expands into other diseases in hematology and oncology.

ANNALS OF ONCOLOGY (2021)

Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Immunology

Cytokine Regulation and Function in T Cells

Chen Dong

Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Article Hematology

CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy

Fraser Soares et al.

Summary: AMl remains a devastating disease for which new therapies are needed. Targeted adoptive T-cell therapies have shown promise in some leukemias but not in AML. A study utilizing CRISPR/Cas9 screens identified SAGA and CD64 as key factors influencing the sensitivity of AML cells to DNT therapy.

BLOOD (2021)

Review Immunology

T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing

Chen Liu et al.

Summary: Single-cell RNA sequencing (scRNA-seq) has enabled the study of rare but crucial progenitors/precursors in mammalian T cell development, leading to remarkable progress in identifying and characterizing early thymic progenitors and delineating the refined developmental trajectories of conventional and unconventional T cells.

TRENDS IN IMMUNOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Hematology

Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production

Jong Bok Lee et al.

Summary: The combination therapy of Venetoclax and azacytidine directly activates T cells, increases reactive oxygen species generation, and enhances cytotoxicity against AML cells. Azacytidine also activates the STING/cGAS pathway, rendering AML cells more susceptible to T cell-mediated cytotoxicity.

BLOOD (2021)

Article Oncology

Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib

Hyeonjeong Kang et al.

Summary: This study investigated the persistence of DNTs in patient-derived xenograft models for the first time, and found that the use of PI3Kd inhibitor can increase the survival rate and in vivo adaptability of DNTs, enhance the efficacy against leukemia, and improve the durability of treatment response.

CANCERS (2021)

Review Immunology

Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy

Amrita Basu et al.

Summary: This review highlights the importance of T-H cells in cancer immunotherapy, discussing the regulation of different subtypes by various immune cells and the impact of contradictory signals on treatment outcomes. Understanding the complexities of CD4(+) T-H cells and balancing anti- vs pro-tumorigenic subtypes is crucial for designing effective immunotherapies.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Transcriptome landscape of double negative T cells by single-cell RNA sequencing

Lu Yang et al.

Summary: The study used single-cell RNA sequencing to analyze DNT cells, revealing transcriptional characteristics and functional roles of different subsets, which contributes to a better understanding of their roles in the immune system.

JOURNAL OF AUTOIMMUNITY (2021)

Article Immunology

NKG2D Enhances Double-Negative T Cell Regulation of B Cells

Shi-hua Hu et al.

Summary: This study presents a possible mechanism for inducing nonregulatory CD4(+) T cells to become regulatory double-negative T (iDNT) cells in vitro. Immature bone marrow dendritic cells were found to induce high levels of iDNT cells, with anti-MHC-II antibody significantly increasing induction. NKG2D expression on iDNT cells enhanced their regulatory function.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy

Dongyao Wang et al.

Summary: Patients with chronic hepatitis B often do not respond well to IFN-alpha therapy. However, sequential IL-2 therapy has shown efficacy in increasing the frequency and function of HBV-specific CD8(+) T cells, leading to improved clinical outcomes for non-responder CHB patients. This suggests a potential new therapeutic approach for refractory CHB patients.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

Review Biotechnology & Applied Microbiology

Translating gammadelta (gamma delta) T cells and their receptors into cancer cell therapies

Zsolt Sebestyen et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Pathology

Causes of double-negative T-cell lymphocytosis in children and adults

Konstantinos Liapis et al.

JOURNAL OF CLINICAL PATHOLOGY (2020)

Article Cell Biology

TCR-α/β CD4- CD8- double negative T cells arise from CD8+ T cells

Noe Rodriguez-Rodriguez et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

Review Hematology

Current Use of and Trends in Hematopoietic Cell Transplantation in the United States

Anita D'Souza et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2020)

Article Biology

Global dynamics of healthy and cancer cells competing in the hematopoietic system

Morten Andersen et al.

MATHEMATICAL BIOSCIENCES (2020)

Review Medicine, General & Internal

CAR-NK cells: A promising cellular immunotherapy for cancer

Guozhu Xie et al.

EBIOMEDICINE (2020)

Review Oncology

DNT Cell-based Immunotherapy: Progress and Applications

Yingrui Li et al.

JOURNAL OF CANCER (2020)

Review Oncology

Bone marrow niches in haematological malignancies

Simon Mendez-Ferrer et al.

NATURE REVIEWS CANCER (2020)

Article Cell Biology

Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

Elise Alspach et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

Article Hematology

Double-Negative T Cell Levels Correlate with Chronic Graft-versus-Host Disease Severity

Erin E. Hillhouse et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2019)

Article Oncology

Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Linan Fang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Editorial Material Biotechnology & Applied Microbiology

Adoptive Cell Therapy: ACT-Up or ACT-Out?

Malcolm K. Brenner

MOLECULAR THERAPY (2019)

Review Biotechnology & Applied Microbiology

Next-generation regulatory T cell therapy

Leonardo M. R. Ferreira et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Multidisciplinary Sciences

Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice

Subhadip Kundu et al.

SCIENTIFIC REPORTS (2019)

Article Urology & Nephrology

Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2

Mohanraj Sadasivam et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Gastroenterology & Hepatology

Antipancreatic cancer effect of DNT cells and the underlying mechanism

Jiong Chen et al.

PANCREATOLOGY (2019)

Article Oncology

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Branson Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Review Medicine, General & Internal

Antibody-Mediated Rejection of Solid-Organ Allografts

Alexandre Loupy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

Natural killer cells and other innate lymphoid cells in cancer

Laura Chiossone et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Education, Scientific Disciplines

HLA donor-specific antibodies in allogeneic hematopoietic stem cell transplantation: challenges and opportunities

Douglas E. Gladstone et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2017)

Article Biochemistry & Molecular Biology

DNT cell inhibits the growth of pancreatic carcinoma via abnormal expressions of NKG2D and MICA in vivo

Hong Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Multidisciplinary Sciences

The biology of innate lymphoid cells

David Artis et al.

NATURE (2015)

Review Cell Biology

Double Negative (DN) αβ T Cells: misperception and overdue recognition

Maria N. Martina et al.

IMMUNOLOGY AND CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Fas death receptor signalling: roles of Bid and XIAP

T. Kaufmann et al.

CELL DEATH AND DIFFERENTIATION (2012)

Review Cell Biology

Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions

Stephen C. Juvet et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2012)

Article Pharmacology & Pharmacy

CD3+CD4-CD8- (double negative) T cells: Saviours or villains of the immune response?

Fulvio D'Acquisto et al.

BIOCHEMICAL PHARMACOLOGY (2011)

Article Immunology

Regulation of antigen-expressing dendritic cells by double negative regulatory T cells

Julia Fang Gao et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2011)

Review Immunology

Plasticity of CD4+ T Cell Lineage Differentiation

Liang Zhou et al.

IMMUNITY (2009)

Article Immunology

TCR signal strength influences αβ/γδ lineage fate

SM Hayes et al.

IMMUNITY (2005)

Letter Immunology

What is trogocytosis and what is its purpose?

E Joly et al.

NATURE IMMUNOLOGY (2003)

Article Immunology

Inhibition of graft-versus-host disease by double-negative regulatory T cells

KJ Young et al.

JOURNAL OF IMMUNOLOGY (2003)

Article Immunology

The nature and mechanisms of DN regulatory T-Cell mediated suppression

KJ Young et al.

HUMAN IMMUNOLOGY (2002)