Journal
CURRENT OPINION IN ELECTROCHEMISTRY
Volume 32, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.coelec.2021.100901
Keywords
microRNA (miRNA); Electrochemiluminescence (ECL); ECL sensors; Point-of-need detection; Medical diagnosis
Funding
- National Natural Science Foundation of China (NSFC) [201804049]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [DG RGPIN-2013-201697, DG RGPIN-2018-06556, SPG STPGP-2016-493924]
- Canada Foundation of Innovation/Ontario Innovation Trust (CFI/OIT) [9040]
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This short review summarizes the bioanalytical strategies currently employed in electrochemiluminescence (ECL) detections of microRNAs (miRNAs), which have an extremely low detection limit and show great potential for point-of-need testing of diseases.
The ultrasensitive detection of microRNAs (miRNAs) is currently pursued for the diagnosis of diseases. Due to its outstanding sensitivity, electrochemiluminescence (ECL) is expected to be very effective toward the above goal. In this short review, bioanalytical strategies currently employed in ECL detections of miRNAs are summarized. ECL sensors based on electrochemiluminescent resonance energy transfer ment reaction (SDR), and other strategies, have an extremely low detection limit of 10-18 M miRNA. In particular, the establishment of miniaturized ECL sensors has shown great potential for point-of-need testing of diseases.
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