Is conservative management of ductal carcinoma in situ risky?

Nonsurgical management of ductal carcinoma in situ is controversial and little is known about the long-term consequences of this approach. In this study, we aimed to determine the risk of (a) upstaging to invasive carcinoma at excision and (b) ipsilateral breast cancer events in patients who might have been eligible for nonsurgical management of DCIS trials. Data from women aged 20 years or older with a biopsy diagnosis of DCIS between January 1, 2010 to December 31, 2014 were collated. The women underwent biopsy and surgical resection (lumpectomy or mastectomy) and were treated with radiation or endocrine therapy as per treating physicians' choice. The development of ipsilateral breast cancer events (IBEs) was analyzed in patients with at least 5 years of follow-up after standard of care therapy for DCIS. Subset-analysis was undertaken to identify the incidence of IBEs in patients eligible for nonsurgical management trials. The study population consisted of 378 patients with matched cases of biopsy and surgical excision. The overall upstaging rate to IBC was 14.3 and 12.9% for COMET, 8.8% for LORIS, and 10.7% for LORD trial eligible patients. At 5 years of follow-up, similar to 11.5% of overall and trial eligible patients developed IBEs of which approximately half were invasive IBEs. In conclusion, women with DCIS who would have been eligible for nonsurgical management trials have a significantly high risk of developing ipsilateral breast events within 5 years of diagnosis. Better selection criteria are needed to identify DOS patients who are at very low risk for the development of IBC.

Automated summary

The nonsurgical management of ductal carcinoma in situ (DCIS) is controversial with limited understanding of its long-term consequences. This study aimed to assess the risk of upstaging to invasive carcinoma and ipsilateral breast cancer events in patients eligible for nonsurgical management trials. The results showed that these patients had a significantly high risk of developing ipsilateral breast events within 5 years of diagnosis, indicating the need for better selection criteria to identify patients at very low risk for the development of invasive breast cancer (IBC).