Cyclin C: A new responser for chemosensitivity in cancer

Article Oncology

Ubiquitylation of cyclin C by HACE1 regulates cisplatin-associated sensitivity in gastric cancer

Hong-Yue Jiang et al.

Summary: Cyclin C plays a crucial role in the regulation of cisplatin resistance in gastric cancer. The ubiquitylation of cyclin C by HACE1 facilitates mitochondrial fission and ROS production, leading to cell apoptosis. This finding provides new insight into the understanding of cisplatin resistance and its potential therapeutic targets in gastric cancer.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology