Electrospinning polyacrylonitrile (PAN) based nanofiberous membranes synergic with plant antibacterial agent and silver nanoparticles (AgNPs) for potential wound dressing

Polyacrylonitrile (PAN) nanofiberous membranes incorporated with different content of Curcumin (Cur), tannic acid and silver nanoparticles (AgNPs) were successfully fabricated by an electrospinning process. The analytical results from the characterizations including scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and ultraviolet-visible photometry (UV-vis) exhibited good physicochemical properties for the obtained novel electrospun composite membranes. The nanofibers exhibited smooth surface with diameter ranged between 375 and 450 nm. The AgNPs obtained by TA reduction owned an average particle diameter of 19.1 nm. There was a rapid release of AgNPs in the Cur/TA/AgNPs/PAN electrospun composite membranes within 8 h, and then a relatively stable release of AgNPs after 24 h. Sustained drug release tests on Cur revealed that the samples exhibited an initial burst response for the first 24 h, followed by sustained release for up to 192 h, which could be traced by fluorescence to observe changes of Cur. The obtained electrospun Cur/TA/AgNPs/PAN nanofiberous composite membrances exhibited better hydrophilicand positive antimicrobial properties. It was found that thoseelectrospun Cur/TA/AgNPs/PAN nanofiberous composite membrances could rapidly scavenge DPPH radicals within 120 s. The results from in vitro cell compatibility test that normal growth and proliferation of Bone marrow MSCs were noticed on the fiber surface within 5 days, indicating favorable biocompatibility. this novel electrospun Cur/TA/AgNPs/PAN nanofiberous composite membranes can be potentially used as the wound dressing in prevention of free radicals and bacteria to wounds.

Automated summary

Nanofiberous membranes incorporated with curcumin, tannic acid and silver nanoparticles were successfully fabricated by electrospinning. Characterization and analysis showed that the obtained composite membranes had good physicochemical properties and biocompatibility, making them suitable for wound prevention against free radicals and bacteria.