Journal
MATERIALS TODAY COMMUNICATIONS
Volume 31, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtcomm.2022.103659
Keywords
Acidic microenvironment; Acid-targeting peptide; Target delivery system; Photodynamic therapy; Solid tumor
Categories
Funding
- National Natural Science Foundation of China, China [81773556]
- Science and Technology Department of Guangdong Province of China [2015A020211010]
- Southern Medical University [B1040903]
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The heterogeneity of tumor cells and the protective effects of cell membranes hinder targeted tumor therapy. A new acid-targeting peptide showed high affinity to tumor cell membranes in an acidic environment, indicating its potential as a delivery system for targeting solid tumor cells.
Targeted tumor therapy relies on drugs that can distinguish tumor cells from normal cells, especially those that can recognize specific receptors or proteins expressed on the surface of tumor cells. However, the heterogeneity of cells in tumors and the protective effects of cell membranes and lysosomes hinder the effectiveness of targeted tumor therapy. Based on the acidic microenvironment of a solid tumor, we constructed an acid-targeting peptide that can firmly bind to the tumor cell membrane in an acidic condition; thereby, it can be employed as a targeting domain to guide antitumor drugs. After coupling the peptide (P12) to the phototherapeutic agent protoporphyrin IX (PPIX) to build a new compound PPIX-P12, in in vitro studies, we found that PPIX-P12 had a high tendency to bind to cancerous cells and showed strong phototoxicity in an acidic medium. This indicated that the acidtargeting peptide might be a promising delivery system for targeting solid tumor cells.
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