Journal
MATERIALS TODAY COMMUNICATIONS
Volume 30, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtcomm.2021.103101
Keywords
Nanocomposite; Antimicrobial; Antibacterial; Photo-chemo combination therapy; Layered double hydroxides
Categories
Funding
- National Natural Science Foundation of China [81803480, 2167315, 11811530640]
- Chengdu University [2081916010]
- School of Engineering of The University of Edinburgh
- Royal Society [RG150564]
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This study introduces a novel antibiotic nanocomposite that effectively kills various bacteria, including drug-resistant bacteria, through photochemotherapy. The nano composite has potential applications in treating bacterial infections and overcoming bacterial resistance.
Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.
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