Simultaneous Dual Echo Gadolinium Enhanced MR-PET for Evaluation of PET Tracer Delivery in Altered Pathophysiology

Efficacy of diagnostics and therapeutics for brain tumours can be modulated by vascular delivery and blood brain barrier permeability. Simultaneous dynamic gadolinium MR-PET enables independent assessment of vascular delivery and blood brain barrier integrity in a brain tumour animal model in the presence of a PET tracer.Dual echo dynamic gadolinium enhanced gradient echo imaging allows simultaneous calculation of T-2* and T-1 images from the TE image pairs. Relaxivity values then enabled determination of independent T-2*- and T-1-derived gadolinium concentrations simultaneously with measurement of [F-18]DPA-714 neuroinflammation radiotracer delivery.Separate T-2*- and T-1-derived gadolinium concentrations curves were derived in a selection of tumours and normal tissue, reflecting vascular delivery and tissue uptake. Changes in the PET activity curves were seen in tumours and normal tissue, reflecting changes in the MR derived dynamic curves. The dramatic changes in the MR-derived vascular delivery and tissue uptake estimates may improve the understanding of the alteration of delivery and uptake of new theranostic agents.

Automated summary

The study utilized dynamic gadolinium-enhanced magnetic resonance - positron emission tomography to independently evaluate vascular delivery and blood brain barrier integrity in brain tumors. It also observed the dynamic changes of therapeutic agents. This method can provide important information on the alterations of therapeutic agent delivery and uptake.