Chronic nicotine up-regulates hippocampal BDNF-TrkB signaling pathway and ANA-12 inhibits nicotine conditioned place preference in mice

Article Behavioral Sciences

Microinjection of the BDNF receptor antagonist ANA-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of BDNF levels and apoptotic cells in rats

Hassan Jorjani et al.

Summary: This study investigated the effects of the BDNF receptor antagonist ANA-12 on morphine-induced CPP in the NAc and mPFC of rats. The results showed that ANA-12 attenuated the acquisition and expression of morphine-induced CPP, as well as decreased BDNF levels and apoptotic neurons in the NAc during the acquisition phase. Additionally, ANA-12 facilitated extinction but had no effect on reinstatement of morphine CPP, and decreased BDNF levels and apoptotic neurons in the mPFC during the extinction phase. These findings suggest that blocking TrkB with ANA-12 may have therapeutic effects on morphine-associated reward memory and neuronal death in the NAc and mPFC.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2021)

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Article Pharmacology & Pharmacy

Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition

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BRITISH JOURNAL OF PHARMACOLOGY (2015)

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Neurotrophins and their receptors: A convergence point for many signalling pathways

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PSYCHOPHARMACOLOGY (2002)

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Article Neurosciences

Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus

PJ Kenny et al.

MOLECULAR BRAIN RESEARCH (2000)

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Chronic nicotine up-regulates hippocampal BDNF-TrkB signaling pathway and ANA-12 inhibits nicotine conditioned place preference in mice

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Microinjection of the BDNF receptor antagonist ANA-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of BDNF levels and apoptotic cells in rats

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors

Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors

Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition

Neurotrophins and their receptors: A convergence point for many signalling pathways

Nicotine addiction: insights from recent animal studies

Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus

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