Journal
FRONTIERS IN PUBLIC HEALTH
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpubh.2022.799731
Keywords
Native Hawaiians and Other Pacific Islanders; obesity; statin; genetic variations; cultural values; dyslipidemia
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2020/08687-9]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01DK128390-01]
- Hawaii Community Foundation [20ADVC-102166]
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Cardiometabolic disorders are a major health concern in the United States, particularly among indigenous populations like Native Hawaiian and Other Pacific Islanders. High-intensity statin therapy can prevent cardiovascular disease, but it also comes with side effects. Different ethnic groups may experience variations in statin side effects due to sociodemographic, behavioral, and/or biological factors.
Cardiometabolic disorders (CD), including cardiovascular disease (CVD), diabetes, and obesity, are the leading cause of health concern in the United States (U.S.), disproportionately affecting indigenous populations such a Native Hawaiian and Other Pacific Islanders (NHOPI). Dyslipidemia, a prevalent risk factor for the development and progression of CVD, is more prone to occur in NHOPI than other populations in the U.S. High-intensity statin therapy to reduce low-density lipoprotein cholesterol is associated with the prevention of CVD events. However, significant side-effects, such as muscle disorders, have been associated with its use. Different ethnic groups could experience variation in the prevalence of statin side effects due to sociodemographic, behavioral, and/or biological factors. Therefore, identifying the most impactful determinants that can be modified to prevent or reduce statin side effects for individuals from high-risk ethnic minority groups, such as NHOPI, can lead to more effective strategies to reduce health disparities. Thus, our Mini-Review explores the challenging aspects of public health precise strategies in NHOPI taking statins, including a culturally informed additional therapy that could positively impact the NHOPI population.
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