4.7 Review

Can Neuropeptide S Be an Indicator for Assessing Anxiety in Psychiatric Disorders?

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Exploring the role of neuropeptides in depression and anxiety

Tarapati Rana et al.

Summary: Depression is a common mental disorder with significant social and economic impacts. Finding new treatment strategies, particularly targeting neuropeptides, has become crucial in neurobiology.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2022)

Review Chemistry, Medicinal

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Ann-Marie Tobinski et al.

Summary: The roles of the NPS/NPSR1 system in rodents have been extensively studied, but its implications in stress-related disorders and substance abuse in humans remain unclear. Comprehensive descriptions of the NPS/NPSR1 system in stress-relevant and reward-relevant endpoints in humans and rodents are still lacking.

PHARMACEUTICALS (2021)

Article Neurosciences

Human-Specific Neuropeptide S Receptor Variants Regulate Fear Extinction in the Basal Amygdala of Male and Female Mice Depending on Threat Salience

Xabier Bengoetxea et al.

Summary: The study revealed that variants of the NPSR1 gene exhibit different phenotypic correlates in the fear-related circuits of the amygdala, affecting the extinction ability of conditioned fear in mice. This finding provides a new mechanism for explaining the high anxiety sensitivity in individuals carrying the ancestral NPSR1 I107 variant.

BIOLOGICAL PSYCHIATRY (2021)

Review Chemistry, Medicinal

The Neural Network of Neuropeptide S (NPS): Implications in Food Intake and Gastrointestinal Functions

Luca Botticelli et al.

Summary: Neuropeptide S (NPS) acts as the endogenous ligand of the NPS receptor (NPSR) and plays a role in various brain functions, including promoting locomotor activity, behavioral arousal, and anxiolytic effects. Additionally, the NPS system is implicated in drug reward properties and food intake regulation, showing anorexigenic effects and potential for developing novel pharmacological tools for treating aberrant feeding patterns and obesity.

PHARMACEUTICALS (2021)

Review Chemistry, Medicinal

Pharmacology, Physiology and Genetics of the Neuropeptide S System

Rainer K. Reinscheid et al.

Summary: The Neuropeptide S (NPS) system is a relatively new transmitter system that has been extensively studied in terms of its pharmacology, anatomical distribution, and functional involvement in behaviors and immune functions. Genetic variations of the human NPS receptor (NPSR1) have attracted attention, with current hypotheses exploring the genetic linkage with disease and human behaviors. The review also discusses the therapeutic potential of future drugs modulating NPS signaling.

PHARMACEUTICALS (2021)

Article Neurosciences

Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis

Thomas Grund et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Psychiatry

The use of EEG Biofeedback/Neurofeedback in psychiatric rehabilitation

Renata Markiewicz

PSYCHIATRIA POLSKA (2017)

Article Anatomy & Morphology

Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study

Csaba Adori et al.

BRAIN STRUCTURE & FUNCTION (2016)

Review Microbiology

The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids

Mercedes Soares-Silva et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Psychiatry

BDNF as a biomarker in the course and treatment of schizophrenia

Malgorzata Libman-Sokolowska et al.

PSYCHIATRIA POLSKA (2015)

Article Anatomy & Morphology

Neuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons

Csaba Adori et al.

FRONTIERS IN NEUROANATOMY (2015)

Article Neurosciences

The Physiology of BDNF and Its Relationship with ADHD

De-Yi Liu et al.

MOLECULAR NEUROBIOLOGY (2015)

Article Behavioral Sciences

Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress

Justin P. Smith et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2014)

Article Psychology, Biological

Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans

Robert Kumsta et al.

BIOLOGICAL PSYCHOLOGY (2013)

Review Medicine, Research & Experimental

Oxidative stress and natural antioxidant mechanisms: the role in neurodegeneration. From molecular mechanisms to therapeutic strategies

Agata Karpinska et al.

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2013)

Review Biochemistry & Molecular Biology

Thrombospondins as key regulators of synaptogenesis in the central nervous system

W. Christopher Risher et al.

MATRIX BIOLOGY (2012)

Review Endocrinology & Metabolism

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis

Peter Holzer et al.

NEUROPEPTIDES (2012)

Review Behavioral Sciences

Neural and cellular mechanisms of fear and extinction memory formation

Caitlin A. Orsini et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2012)

Article Neurosciences

Molecular Fingerprint of Neuropeptide S-Producing Neurons in the Mouse Brain

Xiaobin Liu et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2011)

Review Behavioral Sciences

Nucleus incertus-An emerging modulatory role in arousal, stress and memory

Philip J. Ryan et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2011)

Article Neurosciences

Assessment of the Neuropeptide S System in Anxiety Disorders

Jonas Donner et al.

BIOLOGICAL PSYCHIATRY (2010)

Article Neurosciences

Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei

Miriam Goebel et al.

NEUROSCIENCE LETTERS (2009)

Article Pharmacology & Pharmacy

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice

A. Rizzi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Review Neurosciences

Stress, depression, and neuroplasticity: A convergence of mechanisms

Christopher Pittenger et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Article Endocrinology & Metabolism

Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake

Kirsty L. Smith et al.

ENDOCRINOLOGY (2006)

Article Biochemistry & Molecular Biology

Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses

V Pulkkinen et al.

HUMAN MOLECULAR GENETICS (2006)

Review Biochemistry & Molecular Biology

Targeting antioxidants to mitochondria: A new therapeutic direction

SS Sheu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)

Review Biochemistry & Molecular Biology

Oxidative stress and neurodegeneration: where are we now?

Barry Halliwell

JOURNAL OF NEUROCHEMISTRY (2006)

Review Endocrinology & Metabolism

Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress

A. J. Tilbrook et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2006)

Review Clinical Neurology

Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis

JP Herman et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2005)

Review Neurosciences

BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

CR Bramham et al.

PROGRESS IN NEUROBIOLOGY (2005)

Review Biochemistry & Molecular Biology

BDNF in schizophrenia, depression and corresponding animal models

F Angelucci et al.

MOLECULAR PSYCHIATRY (2005)

Review Biochemistry & Molecular Biology

Neuropeptide S: An orphan comes of age

RK Reinscheid et al.

MOLECULAR INTERVENTIONS (2005)

Review Neurosciences

LTP and LTD: An embarrassment of riches

RC Malenka et al.

NEURON (2004)

Review Clinical Neurology

Psychoneuroendocrinological links between chronic stress and depression

GE Tafet et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)

Review Neurosciences

Molecular mechanisms of CaMKII activation in neuronal plasticity

CC Fink et al.

CURRENT OPINION IN NEUROBIOLOGY (2002)