Journal
SUSTAINABLE CHEMISTRY AND PHARMACY
Volume 27, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scp.2022.100696
Keywords
Quinazoline-2; 4(1H; 3H)-dione; Dichloroquinazoline
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Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic compound with diverse biological activities, and has attracted considerable attention in organic and medicinal chemistry. This paper provides an overview of the various manufacturing methods for biologically active compounds based on quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores.
Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic with a wide range of biological functions, including anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities, and other activities, has attracted high attention in organic and medicinal chemistry. As a consequence, all chemists and pharmaceutical chemists should be familiar with the various procedures for producing quinazoline-2,4(1H,3H)-dione. The main purpose of this paper is to provide an overview of the many manufacturing methods for various biological compounds based on the quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores.
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