Journal
DIAGNOSTICS
Volume 12, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics12061350
Keywords
venous thromboembolism; pulmonary embolism; COVID-19; diagnosis; D-dimer; computed tomography
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Venous thromboembolism (VTE), especially acute pulmonary embolism (PE), is a common and potentially fatal complication of COVID-19. Diagnostic strategies for suspected PE in COVID-19 patients are still controversial. This article discusses the current state-of-the-art diagnostic algorithms for acute PE and summarizes the resolution of PE in patients with COVID-19 under anticoagulant treatment.
Venous thromboembolism (VTE), in particular acute pulmonary embolism (PE), has been shown to be a frequent and potentially fatal complication of coronavirus disease 2019 (COVID-19). In response to the observed thrombotic complications, a large number of studies has been devoted to the understanding and management of COVID-19-associated coagulopathy. Notably, only a limited number of mostly retrospective studies has focused on the optimal diagnostic strategy for suspected PE in COVID-19 patients. As in other special populations, the accuracy of diagnostic algorithms for PE-exclusion has been debated in this specific patient subgroup as the specificity of D-dimer assays and clinical decision rules (CDRs) may be lower than normal. From this viewpoint, we discuss the current state-of-the-art diagnostic algorithms for acute PE with a focus on patients with COVID-19 in the perspective of other special patient populations. Furthermore, we summarize current knowledge regarding the natural history of PE resolution with anticoagulant treatment in patients with COVID-19.
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