Exploration of an Alarm Sensor to Detect Infusion Failure Administered by Syringe Pumps

Incorrect medication administration causes millions of undesirable complications worldwide every year. The problem is severe and there are many control systems in the market, yet the exact molecular composition of the solution is not monitored. Here, we propose an alarm sensor based on UV-Vis spectroscopy and refractometry. Both methods are non-invasive and non-destructive as they utilize visible light for the analysis. Moreover, they can be used for on-site or point-of-care diagnosis. UV-Vis-spectrometer detect the absorption of light caused by an electronic transition in an atom or molecule. In contrast a refractometer measures the extent of light refraction as part of a refractive index of transparent substances. Both methods can be used for quantification of dissolved analytes in transparent substances. We show that a sensor combining both methods is capable to discern most standard medications that are used in intensive care medicine. Furthermore, an integration of the alarm sensor in already existing monitoring systems is possible.

Automated summary

Incorrect medication administration causes millions of undesirable complications worldwide annually. This study proposes an alarm sensor based on UV-Vis spectroscopy and refractometry, which are non-invasive and non-destructive methods. They can be used for quantification of dissolved analytes in transparent substances and are capable of discerning standard medications used in intensive care medicine.