Efficient Synthesis of Various Substituted (Thio)Ureas, Semicarbazides, Thiosemicarbazides, Thiazolidones, and Oxadiazole Derived from [2.2]Paracyclophane

The strategies of the syntheses of various (thio)ureas, semicarbazides, thiosemicarbazides, thiazolidones, and oxadiazole derived from the [2.2]paracyclophane molecule are achieved starting with 4-(2.2]paracyclophanyl)isocyanate. The structures of the obtained products were elucidated by NMR, mass spectrometry, and infrared (IR) spectroscopy in addition to high-resolution mass spectrometry (HRMS). X-ray structure analysis was also used to prove the assigned structure.

Automated summary

Various (thio)ureas, semicarbazides, thiosemicarbazides, thiazolidones, and oxadiazole compounds derived from the [2.2]paracyclophane molecule were successfully synthesized starting with 4-(2.2]paracyclophanyl)isocyanate. The structures of the obtained products were determined using NMR, mass spectrometry, infrared spectroscopy, and high-resolution mass spectrometry (HRMS). X-ray crystallography was used to further confirm the assigned structures.